Utilizing proteomics to understand and define hypertension: where are we and where do we go?
Utilizing proteomics to understand and define hypertension: where are we and where do we go?
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DOI：
10.1080/14789450.2018.1493927
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发表时间：
2018-07
影响因子：
3.4
通讯作者：
Nicklin SA
中科院分区：
文献类型：
--
作者：
Delles C;Carrick E;Graham D;Nicklin SA
引言：高血压是一种复杂的多因素心血管疾病。由于不同的机制在不同程度上影响个体的血压，因此发现高血压的新发病机制具有挑战性。然而，存在改善高血压的预防、检测和治疗以减少与高血压相关的心血管疾病相关的全球负担的迫切且未满足的临床需求。涵盖的领域：蛋白质组学技术已被应用于还原论的实验模型，包括血管紧张素II输注模型在啮齿动物和自发性高血压大鼠，以解开参与血压控制和终末器官损伤的机制。在人类中，蛋白质组学研究主要集中在预测和检测器官损伤，特别是心力衰竭和肾脏疾病。虽然只有很少的蛋白质组学研究专门针对人类原发性高血压，但在妊娠期高血压疾病（如先兆子痫）中有更多的数据。我们将回顾这些研究，并讨论蛋白质组学对精准医学方法的影响。专家评论：尽管蛋白质组学研究在高血压中具有潜力，但在这一研究领域取得了适度的进展。为了充分利用蛋白质组学在高血压和其他心血管疾病中的潜力，需要进行标准化的大规模研究。
Introduction: Hypertension is a complex and multifactorial cardiovascular disorder. With different mechanisms contributing to a different extent to an individual’s blood pressure, the discovery of novel pathogenetic principles of hypertension is challenging. However, there is an urgent and unmet clinical need to improve prevention, detection, and therapy of hypertension in order to reduce the global burden associated with hypertension-related cardiovascular diseases. Areas covered: Proteomic techniques have been applied in reductionist experimental models including angiotensin II infusion models in rodents and the spontaneously hypertensive rat in order to unravel mechanisms involved in blood pressure control and end organ damage. In humans proteomic studies mainly focus on prediction and detection of organ damage, particularly of heart failure and renal disease. While there are only few proteomic studies specifically addressing human primary hypertension, there are more data available in hypertensive disorders in pregnancy, such as preeclampsia. We will review these studies and discuss implications of proteomics on precision medicine approaches. Expert commentary: Despite the potential of proteomic studies in hypertension there has been moderate progress in this area of research. Standardized large-scale studies are required in order to make best use of the potential that proteomics offers in hypertension and other cardiovascular diseases.
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DOI：
10.1161/hypertensionaha.115.06849
发表时间：
2016-05
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Ayyadevara S;Mercanti F;Wang X;Mackintosh SG;Tackett AJ;Prayaga SV;Romeo F;Shmookler Reis RJ;Mehta JL
通讯作者：
Mehta JL
DOI：
10.1016/j.cjca.2016.11.023
发表时间：
2017-05
期刊：
The Canadian journal of cardiology
影响因子：
--
作者：
Currie G;Delles C
通讯作者：
Delles C
影响因子：
7
作者：
Atanur, Santosh S.;Birol, Inanc;Aitman, Timothy J.
通讯作者：
Aitman, Timothy J.
影响因子：
8.3
作者：
Fields, LE;Burt, VL;Sorlie, P
通讯作者：
Sorlie, P
影响因子：
8.3
作者：
Aubiniere-Robb, Louise;Jeemon, Panniyammakal;Padmanabhan, Sandosh
通讯作者：
Padmanabhan, Sandosh