RNAi and microRNA: breakthrough technologies for the improvement of plant nutritional value and metabolic engineering
RNAi and microRNA: breakthrough technologies for the improvement of plant nutritional value and metabolic engineering
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RNAi和microRNA：提高植物营养价值和代谢工程的突破性技术
作者：
G. Tang;G. Galili;Xun Zhuang
本文提出了通过代谢工程提高植物营养价值的复杂问题，以及使用RNAi和microRNA技术克服这种复杂性的潜力，重点介绍了几个关键的例子。它还强调了RNAi和microRNA功能的当前知识，并讨论了新的RNAi载体及其应用的发展的最新进展。RNA干扰（RNAi）和微小RNA（miRNA）是生命科学领域最新的突破性发现，获得2006年诺贝尔生理学或医学奖。这些发现的重要性不仅涉及阐明基因表达的基本调控方面，而且涉及其在植物和动物中应用的巨大潜力。本文综述了近年来RNAi和microRNA在植物营养价值改良中的应用，讨论了代谢组学技术在基因工程中的应用，并介绍了相关RNAi和microRNA技术的最新进展。
This article raises the complex issue of improving plant nutritional value through metabolic engineering and the potential of using RNAi and micro RNA technologies to overcome this complexity, focusing on a few key examples. It also highlights current knowledge of RNAi and microRNA functions and discusses recent progress in the development of new RNAi vectors and their applications. RNA interference (RNAi) and microRNA (miRNA) are recent breakthrough discoveries in the life sciences recognized by the 2006 Nobel Prize in Physiology or Medicine. The importance of these discoveries relates not only to elucidating the fundamental regulatory aspects of gene expression, but also to the tremendous potential of their applications in plants and animals. Here, we review recent applications of RNAi and microRNA for improving the nutritional value of plants, discuss applications of metabolomics technologies in genetic engineering, and provide an update on the related RNAi and microRNA technologies.
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影响因子：
7.2
作者：
Davuluri, GR;Tuinen, A;Bowler, C
通讯作者：
Bowler, C
影响因子：
11.4
作者：
Shi, Y
通讯作者：
Shi, Y
影响因子：
14.9
作者：
Xia, XG;Zhou, HX;Xu, ZS
通讯作者：
Xu, ZS
DOI：
10.1073/pnas.060034297
发表时间：
2000-04-25
影响因子：
11.1
作者：
Chuang, CF;Meyerowitz, EM
通讯作者：
Meyerowitz, EM
影响因子：
3.5
作者：
Harrigan, GG;LaPlante, RH;Roth, RA
通讯作者：
Roth, RA