Ventromedial Prefrontal Cortex Drives the Prioritization of Self-Associated Stimuli in Working Memory
Ventromedial Prefrontal Cortex Drives the Prioritization of Self-Associated Stimuli in Working Memory
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腹内侧前额叶皮层驱动工作记忆中自关联刺激的优先级
DOI：
10.1523/jneurosci.1783-20.2020
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发表时间：
2021-01
影响因子：
5.3
通讯作者：
Egner Tobias
中科院分区：
文献类型：
--
作者：
Yin Shouhang;Bi Taiyong;Chen Antao;Egner Tobias
人类在处理自我相关信息时表现出普遍的偏见，包括在工作记忆（WM）中，人们优先考虑维护自我（而不是其他）相关线索。为了阐明这种自我偏见的神经机制，我们配对了自我与他人相关的空间WM任务与功能磁共振成像和经颅直流电刺激（tDCS）的人类参与者的性别。保持自我（超过其他）相关的线索，导致在经典的WM区域（额顶叶皮层）的活动增强，并在上级多体素模式解码的线索位置从视觉皮层。此外，腹内侧前额叶（VMPFC）显示增强的功能连接与WM区域在维护自我相关的线索，预测个人的行为自我优先级的影响。在后续tDCS实验中，我们用兴奋性（阳极）、抑制性（阴极）或假tDCS靶向VMPFC。阴极tDCS消除了自我优先化效应。这些研究结果提供了强有力的证据，VMPFC的因果作用，在驱动自我优先级的影响，在WM和提供了一个独特的窗口到社会，自我参照处理和高层次的认知控制过程之间的相互作用。重要性陈述人们有强烈的倾向于关注与自我相关的刺激，比如他们的名字。这种自我偏见延伸到工作记忆中任意自我相关刺激的自动优先级。由于工作记忆是高层次认知的核心，这种偏见可能会影响我们如何做出决定。因此，了解潜在的大脑机制非常重要。在这里，我们使用神经成像和非侵入性神经刺激技术，以表明在工作记忆中的自我偏见的来源是腹内侧PFC，它调节活动在额顶叶脑区产生优先表示的自我相关的刺激在感觉皮层。因此，这项工作揭示了高层次认知过程中社会动机（自我参照）偏见的大脑回路。
Humans show a pervasive bias for processing self- over other-related information, including in working memory (WM), where people prioritize the maintenance of self- (over other-) associated cues. To elucidate the neural mechanisms underlying this self-bias, we paired a self- versus other-associated spatial WM task with fMRI and transcranial direct current stimulation (tDCS) of human participants of both sexes. Maintaining self- (over other-) associated cues resulted in enhanced activity in classic WM regions (frontoparietal cortex), and in superior multivoxel pattern decoding of the cue locations from visual cortex. Moreover, ventromedial PFC (VMPFC) displayed enhanced functional connectivity with WM regions during maintenance of self-associated cues, which predicted individuals' behavioral self-prioritization effects. In a follow-up tDCS experiment, we targeted VMPFC with excitatory (anodal), inhibitory (cathodal), or sham tDCS. Cathodal tDCS eliminated the self-prioritization effect. These findings provide strong converging evidence for a causal role of VMPFC in driving self-prioritization effects in WM and provide a unique window into the interaction between social, self-referential processing and high-level cognitive control processes. SIGNIFICANCE STATEMENT People have a strong tendency to attend to self-related stimuli, such as their names. This self-bias extends to the automatic prioritization of arbitrarily self-associated stimuli held in working memory. Since working memory is central to high-level cognition, this bias could influence how we make decisions. It is therefore important to understand the underlying brain mechanisms. Here, we used neuroimaging and noninvasive neurostimulation techniques to show that the source of self-bias in working memory is the ventromedial PFC, which modulates activity in frontoparietal brain regions to produce prioritized representations of self-associated stimuli in sensory cortex. This work thus reveals a brain circuit underlying the socially motivated (self-referential) biasing of high-level cognitive processing.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
人脑的注意力系统：20年后。
影响因子：
13.9
作者：
Petersen SE;Posner MI
通讯作者：
Posner MI
影响因子：
19.9
作者：
Jason M. Scimeca;Anastasia Kiyonaga;M. D’Esposito
通讯作者：
Jason M. Scimeca;Anastasia Kiyonaga;M. D’Esposito
影响因子：
--
作者：
Basil Z. de Ferranti
通讯作者：
Basil Z. de Ferranti
DOI：
10.1037/a0029792
发表时间：
2012-10-01
影响因子：
2.1
作者：
Sui, Jie;He, Xun;Humphreys, Glyn W.
通讯作者：
Humphreys, Glyn W.