Fasting Blood Glucose but not TMAO is Associated with In-Stent Restenosis in Patients with Acute Coronary Syndrome
Fasting Blood Glucose but not TMAO is Associated with In-Stent Restenosis in Patients with Acute Coronary Syndrome
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空腹血糖而非TMAO与急性冠状动脉综合征患者的支架内再狭窄相关
DOI：
10.15212/cvia.2021.0034
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发表时间：
2022
影响因子：
0.5
通讯作者：
Ping Zhang
中科院分区：
文献类型：
--
作者：
Ping Zhang
背景资料：方法：采用单中心回顾性病例对照研究方法，将64例PCI术后有症状反复冠状动脉造影的患者和15例ISR患者纳入ISR组，49例无ISR患者纳入非ISR组。结果：ISR组与非ISR组血浆TMAO水平无显著性差异。血浆TMAO水平与ISR无显著相关性，与糖尿病、血清HbA 1c水平和血清肌酐水平均呈显著正相关，且与女性呈显著负相关。ISR与糖尿病、空腹血糖水平、中性粒细胞/淋巴细胞比值、句法评分呈显著正相关;与血小板呈显著负相关。Logistic回归分析显示，空腹血糖是ISR的唯一独立预测因子。结论：血浆TMAO可能与ACS患者DES植入后ISR及斑块负荷无关，而FBG可能预测ACS患者ISR的发生。
Background: The purpose of our study was to assess whether the occurrence of ISR might be associated with plasmaTMAO levels in patients with ACS after DES implantation.Methods: This was a single center retrospective case-control study, in which 64 symptomatic patients with repeatedcoronary angiography after PCI and 15 patients with ISR were included in the ISR group, and 49 patients without ISRwere included in the non-ISR group. High-performance liquid chromatography with tandem mass spectrometry wasused to measure plasma TMAO levels.Results: No significant differences were observed in plasma TMAO between the ISR and non-ISR groups. Plasma TMAO levels showed no significant correlation with ISR, but were significantly positively correlated with diabetes mellitus, serum HbA1c levels and serum creatinine levels; moreover, they were significantly negatively correlated with female sex. ISR was significantly positively correlated with diabetes mellitus, fasting blood glucose levels, the neutrophil to lymphocyte ratio and syntax score; in addition, it was significantly negatively correlated with platelets. Logistic regression analysis indicated that fasting blood glucose was the only independent predictor of ISR.Conclusion: Plasma TMAO may not be associated with ISR and plaque burden in patients with ACS after DES implantation,whereas FBG may predict the development of ISR in these patients.
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DOI：
10.1056/nejmoa1109400
发表时间：
2013-04-25
期刊：
The New England journal of medicine
影响因子：
--
作者：
Tang WH;Wang Z;Levison BS;Koeth RA;Britt EB;Fu X;Wu Y;Hazen SL
通讯作者：
Hazen SL
影响因子：
9.3
作者：
Tang WH;Wang Z;Li XS;Fan Y;Li DS;Wu Y;Hazen SL
通讯作者：
Hazen SL
影响因子：
24
作者：
Senthong V;Li XS;Hudec T;Coughlin J;Wu Y;Levison B;Wang Z;Hazen SL;Tang WH
通讯作者：
Tang WH
影响因子：
2.9
作者：
Wang Z;Levison BS;Hazen JE;Donahue L;Li XM;Hazen SL
通讯作者：
Hazen SL