Muscarinic acetylcholine receptors are expressed by most parvalbumin-immunoreactive neurons in area MT of the macaque.
Muscarinic acetylcholine receptors are expressed by most parvalbumin-immunoreactive neurons in area MT of the macaque.
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DOI：
10.1002/brb3.225
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发表时间：
2014-05
影响因子：
3.1
通讯作者：
Reynolds, John H.
中科院分区：
文献类型：
--
作者：
Disney, Anita A.;Alasady, Hussein A.;Reynolds, John H.
关键词：
在哺乳动物新皮层中，表达小清蛋白的细胞（PV神经元）包括与快速/窄峰生理表型基本上重叠的抑制性神经元的主要类别。注意力对短尾猴纹外皮层的窄峰神经元有明显的影响，而且比它们的宽峰神经元更有影响。乙酰胆碱（ACh）的皮质神经调节是注意力方面的候选机制，在猕猴的初级视觉皮层（V1）中，抑制性神经元强烈表达ACh受体（AChRs）。特别是，猕猴V1的大多数PV神经元表达m1毒蕈碱AChR，外源性ACh可引起γ-氨基丁酸的释放。与此相反，在大鼠V1很少PV神经元表达m1 AChRs。虽然这可能是物种差异，但也有人认为，与猕猴的其他皮质区域相比，猕猴V1在解剖学上是独特的。本研究的目的是更好地了解在何种程度上V1提供了一个合适的模型电路在猕猴枕叶的胆碱能解剖，并探讨胆碱能调制的生物学基础的电路行为的变化与注意。我们比较了猕猴PV神经元之间的V1区和中颞叶视觉区（MT）的m1 AChRs的表达，使用双免疫荧光共聚焦显微镜。我们发现，在V1中，大多数PV神经元在MT中表达M1 AChRs，但与V1不同的是，似乎大多数兴奋性神经元也是如此。这为V1作为猕猴视皮层抑制的胆碱能调制的模型提供了支持，但一般不支持视皮层回路的胆碱能调制。我们还建议，ACh通过M1 AChRs的作用是一个候选人的潜在机制，在行为动物中观察到的窄尖峰神经元的强烈影响的注意。
In the mammalian neocortex, cells that express parvalbumin (PV neurons) comprise a dominant class of inhibitory neuron that substantially overlaps with the fast/narrow-spiking physiological phenotype. Attention has pronounced effects on narrow-spiking neurons in the extrastriate cortex of macaques, and more consistently so than on their broad-spiking neighbors. Cortical neuromodulation by acetylcholine (ACh) is a candidate mechanism for aspects of attention and in the primary visual cortex (V1) of the macaque, receptors for ACh (AChRs) are strongly expressed by inhibitory neurons. In particular, most PV neurons in macaque V1 express m1 muscarinic AChRs and exogenously applied ACh can cause the release of γ-aminobutyric acid. In contrast, few PV neurons in rat V1 express m1 AChRs. While this could be a species difference, it has also been argued that macaque V1 is anatomically unique when compared with other cortical areas in macaques. The aim of this study was to better understand the extent to which V1 offers a suitable model circuit for cholinergic anatomy in the macaque occipital lobe, and to explore cholinergic modulation as a biological basis for the changes in circuit behavior seen with attention. We compared expression of m1 AChRs by PV neurons between area V1 and the middle temporal visual area (MT) in macaque monkeys using dual-immunofluorescence confocal microscopy. We find that, as in V1, most PV neurons in MT express m1 AChRs but, unlike in V1, it appears that so do most excitatory neurons. This provides support for V1 as a model of cholinergic modulation of inhibition in macaque visual cortex, but not of cholinergic modulation of visual cortical circuits in general. We also propose that ACh acting via m1 AChRs is a candidate underlying mechanism for the strong effects of attention on narrow-spiking neurons observed in behaving animals.
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影响因子：
64.8
作者：
Herrero, J. L.;Roberts, M. J.;Delicato, L. S.;Gieselmann, M. A.;Dayan, P.;Thiele, A.
通讯作者：
Thiele, A.
影响因子：
2.5
作者：
Disney, Anita A.;Domakonda, Kunal V.;Aoki, Chiye
通讯作者：
Aoki, Chiye
单胞菌素 - 免疫反应性神经元在原发性视觉皮层中的M1型毒蕈碱乙酰胆碱受体的表达：大鼠，豚鼠，雪貂，猕猴和人类的比较研究。
影响因子：
2.5
作者：
Disney, Anita A.;Reynolds, John H.
通讯作者：
Reynolds, John H.
影响因子：
4
作者：
CELIO, MR;BAIER, W;GERDAY, C
通讯作者：
GERDAY, C
DOI：
10.1002/cne.22111
发表时间：
2009-10-01
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
Constantinople CM;Disney AA;Maffie J;Rudy B;Hawken MJ
通讯作者：
Hawken MJ