Regulatory T cells in many flavors control asthma.
Regulatory T cells in many flavors control asthma.
复制标题
作者：
调节性T细胞（Treg）在控制哮喘等过敏性疾病方面发挥着至关重要的作用，这一点现在是无可争议的。Treg介导的过敏性哮喘抑制中最常见的细胞因子是TGF-β和IL-10。除了天然存在的Tcl 4外，在最近的研究中已经证明了适应性Tcl 4，其响应于外来抗原而诱导。诱导性/适应性T细胞（iT细胞）的概念在预防哮喘方面具有相当大的意义，如果在生命早期产生的话。这是因为细胞因子如IL-4和IL-6抑制初始CD 4 + T细胞中的Foxp 3诱导，因此当TcR伴随着响应过敏原的效应细胞发育时，可以预期TcR的从头产生效率较低。然而，如果可以诱导iTreg，则感染耐受的过程将促进iTreg库的扩增，如最近文献中所建议的。很容易推测，在相对不成熟的免疫系统的背景下，在早期生活中存在一个机会之窗，该免疫系统允许产生对过敏原谱特异性的iTlase，该过敏原将终生调节哮喘。本综述的重点是nTclad和iTclad在控制哮喘从生命早期到成年期的相关性，Treg功能的机制以及利用我们目前的概念来充分利用Tclad的潜力来限制疾病的发展和进展的前景。
That regulatory T cells (Tregs) have a crucial role in controlling allergic diseases such as asthma is now undisputed. The cytokines most commonly implicated in Treg-mediated suppression of allergic asthma are TGF-β and IL-10. In addition to naturally occurring Tregs, adaptive Tregs, induced in response to foreign antigens, have been demonstrated in recent studies. The concept of inducible/adaptive Tregs (iTregs) has considerable significance in preventing asthma if generated early enough in life. This is because cytokines such as IL-4 and IL-6 inhibit Foxp3 induction in naïve CD4+ T cells and therefore de novo generation of Tregs can be expected to be less efficient when it is concomitant with effector cell development in response to an allergen. However, if iTregs can be induced, the process of infectious tolerance would facilitate expansion of the iTreg pool as suggested in the recent literature. It is tempting to speculate that there is a window of opportunity in early life in the context of a relatively immature immune system that is permissive for the generation of iTregs specific to a spectrum of allergens that would regulate asthma lifelong. The focus of this review is the relevance of nTregs and iTregs in controlling asthma from early life into adulthood, the mechanisms underlying Treg function and the prospects for utilizing our current concepts to harness the full potential of Tregs to limit disease development and progression.
登录
查看更多内容
影响因子：
30.5
作者：
Acosta-Rodriguez, Eva V.;Napolitani, Giorgio;Sallusto, Federica
通讯作者：
Sallusto, Federica
影响因子：
15.3
作者：
Apostolou, I;von Boehmer, H
通讯作者：
von Boehmer, H
影响因子：
32.4
作者：
Barrett, Nora A.;Austen, K. Frank
通讯作者：
Austen, K. Frank
影响因子：
30.8
作者：
Bennett, CL;Christie, J;Ochs, HD
通讯作者：
Ochs, HD
影响因子：
4.4
作者：
Basu, Samik;Golovina, Tatiana;Riley, James L.
通讯作者：
Riley, James L.