Compact NMR relaxometry of human blood and blood components.
Compact NMR relaxometry of human blood and blood components.
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DOI：
10.1016/j.trac.2016.04.020
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发表时间：
2016-11
影响因子：
13.1
通讯作者：
Robinson, Michelle D.
中科院分区：
文献类型：
--
作者：
Cistola, David P.;Robinson, Michelle D.
关键词：
核磁共振弛豫测量是 NMR 技术的一种独特实用且多功能的实施方式。由于它不依赖于化学位移分辨率，因此可以使用在非典型环境中部署的低场紧凑型仪器来执行。早期对人体血液的松弛测量研究主要集中在开发癌症诊断测试。这些努力是错误的，因为测量结果并非针对癌症。然而，关于驱动水纵向 (T1) 和横向 (T2) 弛豫时间的因素，我们学到了重要的经验教训。一个关键因素是蛋白质和脂蛋白的总体分布。血浆水 T2 可以检测由炎症、胰岛素抵抗和血脂异常引起的血液蛋白质组变化。在全血中，T2 对血红蛋白含量和氧合敏感，尽管后者可以通过操纵静态和外加磁场来抑制。紧凑型核磁共振弛豫测量法目前的应用包括念珠菌病、止血、疟疾和胰岛素抵抗的血液检测。
Nuclear magnetic resonance relaxometry is a uniquely practical and versatile implementation of NMR technology. Because it does not depend on chemical shift resolution, it can be performed using low-field compact instruments deployed in atypical settings. Early relaxometry studies of human blood were focused on developing a diagnostic test for cancer. Those efforts were misplaced, as the measurements were not specific to cancer. However, important lessons were learned about the factors that drive the water longitudinal (T1) and transverse (T2) relaxation times. One key factor is the overall distribution of proteins and lipoproteins. Plasma water T2 can detect shifts in the blood proteome resulting from inflammation, insulin resistance and dyslipidemia. In whole blood, T2 is sensitive to hemoglobin content and oxygenation, although the latter can be suppressed by manipulating the static and applied magnetic fields. Current applications of compact NMR relaxometry include blood tests for candidiasis, hemostasis, malaria and insulin resistance.
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影响因子：
3.3
作者：
GASPAROVIC, C;MATWIYOFF, NA
通讯作者：
MATWIYOFF, NA
影响因子：
5.5
作者：
Granwehr, Josef;Roberts, Peter J.
通讯作者：
Roberts, Peter J.
影响因子：
2.2
作者：
Danieli, Ernesto;Bluemich, Bernhard
通讯作者：
Bluemich, Bernhard
影响因子：
2.2
作者：
Ghosh, Supriyo;Keener, Kevin M.;Pan, Yong
通讯作者：
Pan, Yong
DOI：
10.1016/0005-2795(76)90267-1
发表时间：
1976-01-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
GROSCH, L;NOACK, F
通讯作者：
NOACK, F