Sustained versus instantaneous connectivity differentiates cognitive functions of processing speed and episodic memory.
Sustained versus instantaneous connectivity differentiates cognitive functions of processing speed and episodic memory.
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DOI：
10.1002/hbm.24336
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发表时间：
2018-12
影响因子：
4.8
通讯作者：
Anderson JS
中科院分区：
文献类型：
--
作者：
King JB;Anderson JS
大脑活动随时间的同步性描述了大脑区域之间的功能连接，但没有解决这种关系的时间组成部分。我们提出了一种互补的分析方法，通过引入功能性磁共振成像（fMRI）时间序列之间的互相关曲线的宽度作为衡量大脑区域之间的同步活动的相对持续时间，或“持续连接”。使用人类连接组项目中1003名受试者的静息状态fMRI，认知和人口统计学数据，我们发现持续的连接在个体中是一种可重复的特征，是可遗传的，在女性中更短暂，并在成年早期显示出随年龄的变化。大脑感觉区域的持续连通性与受试者之间的处理速度差异特别相关，特别是在男性中。相比之下，传统的功能连接与情景记忆的测量相关，但与处理速度无关。血液动力学反应函数（HRF）的个体差异与持续连接密切相关，HRF的宽度也与个体间的处理速度相关，这表明血液动力学反应的变异性可能受到短暂与持续神经活动的影响，而不仅仅是血管分布和信号转导的差异。持续的连接可能为研究临床人群的脑动力学提供新的机会。
Synchrony of brain activity over time describes the functional connectivity between brain regions but does not address the temporal component of this relationship. We propose a complementary method of analysis by introducing the width of cross-correlation curves between functional MRI (fMRI) time series as a metric of the relative duration of synchronous activity between brain regions, or “sustained connectivity”. Using resting-state fMRI, cognitive, and demographics data from 1003 subjects included in the Human Connectome Project, we find that sustained connectivity is a reproducible trait in individuals, is heritable, more transient in females, and shows changes with age in early adulthood. Sustained connectivity in sensory brain regions is specifically associated with differences in processing speed across subjects, particularly in men. In contrast, traditional functional connectivity was correlated with a measure of episodic memory, but not with processing speed. Individual differences in hemodynamic response function (HRF) are closely approximated by sustained connectivity and width of the HRF is also correlated with processing speed across individuals, suggesting that variability in hemodynamic response may be influenced by transient vs. sustained neural activity rather than simply differences in vascularity and signal transduction. Sustained connectivity may provide new opportunities to study brain dynamics in clinical populations.
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影响因子：
5.7
作者：
Arbabshirani MR;Damaraju E;Phlypo R;Plis S;Allen E;Ma S;Mathalon D;Preda A;Vaidya JG;Adali T;Calhoun VD
通讯作者：
Calhoun VD
DOI：
10.1073/pnas.0901831106
发表时间：
2009-06-23
影响因子：
11.1
作者：
Deco, Gustavo;Jirsa, Viktor;Koetter, Rolf
通讯作者：
Koetter, Rolf
影响因子：
3.7
作者：
Allen, Elena A.;Damaraju, Eswar;Calhoun, Vince D.
通讯作者：
Calhoun, Vince D.
影响因子：
4.6
作者：
Deco, Gustavo;Kringelbach, Morten L.;Ritter, Petra
通讯作者：
Ritter, Petra
DOI：
10.1111/mono.12036
发表时间：
2013-08-01
影响因子：
9.5
作者：
Carlozzi, Noelle E.;Tulsky, David S.;Beaumont, Jennifer L.
通讯作者：
Beaumont, Jennifer L.