Association between circulating tumor necrosis factor-related biomarkers and estimated glomerular filtration rate in type 2 diabetes.
Association between circulating tumor necrosis factor-related biomarkers and estimated glomerular filtration rate in type 2 diabetes.
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循环肿瘤坏死因子相关生物标志物与2型糖尿病的肾小球滤过率之间的关联。
DOI：
10.1038/s41598-018-33590-w
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发表时间：
2018-10-17
影响因子：
4.6
通讯作者：
Gohda T
中科院分区：
文献类型：
--
作者：
Kamei N;Yamashita M;Nishizaki Y;Yanagisawa N;Nojiri S;Tanaka K;Yamashita Y;Shibata T;Murakoshi M;Suzuki Y;Gohda T
慢性炎症在糖尿病肾病的发生/进展中起着至关重要的作用。研究肿瘤坏死因子（TNF）相关生物标志物[TNFα、前颗粒蛋白（PGRN）、TNF受体（TNFR1和TNFR2）]和尿酸（UA）在2型糖尿病（T2D）患者肾功能下降中的作用。对594例日本t2dm患者血清tnf相关生物标志物和UA水平进行检测，eGFR≥30 mL/min/1.73 m2。四种tnf相关生物标志物和UA与估计的肾小球滤过率（eGFR）呈负相关。在logistic多变量模型中，校正相关协变量（基本模型）后，每个tnf相关生物标志物和UA与eGFR降低（eGFR <60mL /min/1.73 m2）相关。此外，在受试者工作特征曲线分析中，与基本模型（UA， ΔAUC, 0.049, p < 0.001; TNFα， ΔAUC, 0.022, p = 0.007; TNFR1， ΔAUC, 0.064, p < 0.001; TNFR2， ΔAUC, 0.052, p < 0.001）一起测量时，UA和除PGRN外的tnf相关生物标志物对降低eGFR的危险因素有显著的益处。TNFR配体与较低的eGFR相关，但在eGFR≥30 mL/min/1.73 m2的T2D患者中，与TNFR配体或UA的相关性不如前者强。
Chronic inflammation plays a crucial role in the development/progression of diabetic kidney disease. The involvement of tumor necrosis factor (TNF)-related biomarkers [TNFα, progranulin (PGRN), TNF receptors (TNFR1 and TNFR2)] and uric acid (UA) in renal function decline was investigated in patients with type 2 diabetes (T2D). Serum TNF-related biomarkers and UA levels were measured in 594 Japanese patients with T2D and an eGFR ≥30 mL/min/1.73 m2. Four TNF-related biomarkers and UA were negatively associated with estimated glomerular filtration rate (eGFR). In a logistic multivariate model, each TNF-related biomarker and UA was associated with lower eGFR (eGFR <60mL /min/1.73 m2) after adjustment for relevant covariates (basic model). Furthermore, UA and TNF-related biomarkers other than PGRN added a significant benefit for the risk factors of lower eGFR when measured together with a basic model (UA, ΔAUC, 0.049, p < 0.001; TNFα, ΔAUC, 0.022, p = 0.007; TNFR1, ΔAUC, 0.064, p < 0.001; TNFR2, ΔAUC, 0.052, p < 0.001) in receiver operating characteristic curve analysis. TNFR ligands were associated with lower eGFR, but the associations were not as strong as those with TNFRs or UA in patients with T2D and an eGFR ≥30 mL/min/1.73 m2.
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影响因子：
4.2
作者：
Maahs, David M.;Caramori, Luiza;Cherney, David Z. I.;Galecki, Andrzej T.;Gao, Chuanyun;Jalal, Diana;Perkins, Bruce A.;Pop-Busui, Rodica;Rossing, Peter;Mauer, Michael;Doria, Alessandro
通讯作者：
Doria, Alessandro
影响因子：
3.7
作者：
Lee JH;Park DY;Lee KJ;Kim YK;So YK;Ryu JS;Oh SH;Han YS;Ko K;Choo YK;Park SJ;Brodzik R;Lee KK;Oh DB;Hwang KA;Koprowski H;Lee YS;Ko K
通讯作者：
Ko K
肿瘤坏死因子受体1和2与2型糖尿病的早期肾小球病变有关。
影响因子：
19.6
作者：
Pavkov ME;Weil EJ;Fufaa GD;Nelson RG;Lemley KV;Knowler WC;Niewczas MA;Krolewski AS
通讯作者：
Krolewski AS
影响因子：
5.4
作者：
Carlsson, Axel C.;Ruge, Toralph;Arnlov, Johan
通讯作者：
Arnlov, Johan
影响因子：
13.6
作者：
Niewczas, Monika A.;Gohda, Tomohito;Krolewski, Andrzej S.
通讯作者：
Krolewski, Andrzej S.