In Utero Origins of Acute Leukemia in Children.
In Utero Origins of Acute Leukemia in Children.
复制标题
儿童急性白血病的病因。
DOI：
10.3390/biomedicines12010236
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发表时间：
2024-01-19
期刊：
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
急性白血病主要包括急性淋巴细胞白血病（ALL）和急性髓系白血病（AML），是血液学癌症的主要诊断组。特别是由于急性淋巴细胞白血病发病年龄较早，长期以来人们一直怀疑儿童急性白血病可能有子宫起源。这一假设激发了许多寻求产前白血病发生的直接证据的调查，特别是双胞胎和“回溯研究”。怀疑的子宫起源也集中在妊娠期作为一个关键的风险窗口，导致了丰富的文献产前危险因素的儿科急性白血病。在这个叙述性的回顾，我们重新叙述了儿童急性白血病的子宫起源的间接和直接的证据。
Acute leukemias, mainly consisting of acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), comprise a major diagnostic group among hematologic cancers. Due to the early age at onset of ALL, particularly, it has long been suspected that acute leukemias of childhood may have an in utero origin. This supposition has motivated many investigations seeking direct proof of prenatal leukemogenesis, in particular, twin and “backtracking studies”. The suspected in utero origin has also focused on gestation as a critical window of risk, resulting in a rich literature on prenatal risk factors for pediatric acute leukemias. In this narrative review, we recount the circumstantial and direct evidence for an in utero origin of childhood acute leukemias.
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影响因子：
11.4
作者：
Greaves M;Cazzaniga V;Ford A
通讯作者：
Ford A
影响因子：
51.1
作者：
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Pieters, Rob
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6.4
作者：
Moore KJ;Hubbard AK;Williams LA;Spector LG
通讯作者：
Spector LG
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Gu, Zhaohui;Churchman, Michelle;Roberts, Kathryn;Li, Yongjin;Liu, Yu;Harvey, Richard C.;McCastlain, Kelly;Reshmi, Shalini C.;Payne-Turner, Debbie;Iacobucci, Ilaria;Shao, Ying;Chen, I-Ming;Valentine, Marcus;Pei, Deqing;Mungall, Karen L.;Mungall, Andrew J.;Ma, Yussanne;Moore, Richard;Marra, Marco;Stonerock, Eileen;Gastier-Foster, Julie M.;Devidas, Meenakshi;Dai, Yunfeng;Wood, Brent;Borowitz, Michael;Larsen, Eric E.;Maloney, Kelly;Mattano, Leonard A., Jr.;Angiolillo, Anne;Salzer, Wanda L.;Burke, Michael J.;Gianni, Francesca;Spinelli, Orietta;Radich, Jerald P.;Minden, Mark D.;Moorman, Anthony V.;Patel, Bella;Fielding, Adele K.;Rowe, Jacob M.;Luger, Selina M.;Bhatia, Ravi;Aldoss, Ibrahim;Forman, Stephen J.;Kohlschmidt, Jessica;Mrozek, Krzysztof;Marcucci, Guido;Bloomfield, Clara D.;Stock, Wendy;Kornblau, Steven;Kantarjian, Hagop M.;Konopleva, Marina;Paietta, Elisabeth;Willman, Cheryl L.;Loh, Mignon L.;Hunger, Stephen P.;Mullighan, Charles G.
通讯作者：
Mullighan, Charles G.
影响因子：
6.4
作者：
Bailey, Helen D.;Infante-Rivard, Claire;Schuez, Joachim
通讯作者：
Schuez, Joachim