Childhood cancer incidence among specific Asian and Pacific Islander populations in the United States.
Childhood cancer incidence among specific Asian and Pacific Islander populations in the United States.
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DOI：
10.1002/ijc.33153
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发表时间：
2020-12-15
影响因子：
6.4
通讯作者：
Spector LG
中科院分区：
文献类型：
--
作者：
Moore KJ;Hubbard AK;Williams LA;Spector LG
尽管亚洲有着巨大的遗传和环境多样性，但在美国，亚洲和太平洋岛民（API）血统的个体经常被合并成一个单一的群体进行流行病学分析。我们使用监测、流行病学和最终结果（SEER）详细的亚洲/太平洋岛民数据库来计算0-19岁儿童中离散组的发病率。由于样本量的限制，我们根据原籍国汇总了东亚人（中国人、日本人、韩国人）、东南亚人（越南人、老挝人、柬埔寨人）、亚洲印度人/巴基斯坦人、大洋洲人（关岛人、萨摩亚人、汤加人）和菲律宾人的发病率。计算每个API区域组与非西班牙裔白人（NHW）和东亚人的发病率比（IRR）和95%置信区间（CI）。最后，我们计算了SEER中特定API种族的癌症发病率与五大洲癌症发病率原产国的癌症发病率之间的相关性。API区域组的发病率各不相同。急性淋巴细胞白血病（ALL）在东南亚裔儿童中的发病率较低（IRR 0.65, 95% CI 0.44, 0.96）。急性髓性白血病（AML）在大洋洲儿童中更为常见（IRR 3.88, 95% CI 1.83, 8.22）。东亚儿童的发病率高于东南亚儿童，但与大洋洲儿童相比发病率较低。一些发病率在美国API种族和原产国之间的相关性是相似的。在API组中观察到的儿童癌症发病率模式的差异可能表明潜在遗传学和/或暴露模式的差异。
Despite the vast genetic and environmental diversity in Asia, individuals of Asian and Pacific Islander (API) descent are often combined into a single group for epidemiologic analyses within the United States. We used the Surveillance, Epidemiology, and End Results (SEER) Detailed Asian/Pacific Islander Database to calculate incidence rates for discrete groups among children aged 0–19 years. Due to sample size constraints we pooled incidence among regional groups based on countries of origin: East Asians (Chinese, Japanese, Korean), Southeast (SE) Asians (Vietnamese, Laotian, Cambodian), Asian Indian/Pakistani, Oceanians (Guamanian, Samoan, Tongan), and Filipinos. Incidence rate ratios (IRR) and 95% confidence intervals (CI) were calculated comparing each API regional group to Non-Hispanic Whites (NHW) and East Asians. Lastly, we calculated the correlation between incidence of cancer in specific API ethnicities in SEER and in originating countries in the Cancer Incidence i n Five Continents. Incidence rates among API regional groups varied. Acute lymphoblastic leukemia (ALL) was lower in children of SE Asian descent (IRR 0.65, 95% CI 0.44, 0.96) compared to NHW. Acute myeloid leukemia (AML) was more common among children from Oceania compared to NHW (IRR 3.88, 95% CI 1.83, 8.22). East Asians had higher incidence rates than SE Asians but lower rates compared to children from Oceania. Correlation of some incidence rates between US-based API ethnicities and originating countries were similar. The variation observed in childhood cancer incidence patterns among API groups may indicate differences in underlying genetics and/or patterns of exposure.
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DOI：
10.1097/00001648-199001000-00010
发表时间：
1990-01-01
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Rothman, K J
通讯作者：
Rothman, K J
影响因子：
64.5
作者：
Browning SR;Browning BL;Zhou Y;Tucci S;Akey JM
通讯作者：
Akey JM
影响因子：
3.8
作者：
Ng CJ;Teo CH;Abdullah N;Tan WP;Tan HM
通讯作者：
Tan HM
影响因子：
2.3
作者：
Miller, Barry A.;Chu, Kenneth C.;Hankey, Benjamin F.;Ries, Lynn A. G.
通讯作者：
Ries, Lynn A. G.
影响因子：
6.4
作者：
Le, GM;Gomez, SL;West, DW
通讯作者：
West, DW