Mechanical regulation of cell-cycle progression and division.

Mechanical regulation of cell-cycle progression and division.
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DOI:
10.1016/j.tcb.2022.03.010
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发表时间:
2022-09
影响因子:
19
通讯作者:
Chaudhuri, Ovijit
Chaudhuri, Ovijit
中科院分区:
生物学1区
文献类型:
--
作者:
Gupta, Vivek K.;Chaudhuri, Ovijit

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细胞周期进程和分裂是动物细胞的基本生物学过程,其生化调控已被广泛研究。一项新兴的工作揭示了细胞与组织中微环境的机械相互作用,包括与细胞外基质(ECM)和邻近细胞的相互作用,在调节细胞周期进展和分裂方面也发挥了关键作用。在这里,我们回顾了最近关于细胞如何解释物理线索并改变其机制以促进细胞周期进展和启动细胞分裂的工作,然后回顾了关于分裂细胞如何在其周围的微环境中产生力量以成功分裂的工作。最后,文章最后讨论了在分裂过程中的力量产生如何潜在地有助于更大的组织规模的过程,涉及到发育和动态平衡。
Cell cycle progression and division are fundamental biological processes in animal cells, and their biochemical regulation has been extensively studied. An emerging body of work has revealed how mechanical interactions of cells with their microenvironment in tissues, including with the extracellular matrix (ECM) and neighboring cells, also plays a critical role in regulating cell cycle progression and division. Here we review recent work on how cells interpret physical cues and alter their mechanics to promote cell cycle progression and initiate cell division, and then on how dividing cells generate forces on their surrounding microenvironment to successfully divide. Finally, the article ends by discussing how force generation during division potentially contributes to larger tissue-scale processes involved in development and homeostasis.
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