Scotopic Vision Is Selectively Processed in Thick-Type Columns in Human Extrastriate Cortex.
Scotopic Vision Is Selectively Processed in Thick-Type Columns in Human Extrastriate Cortex.
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DOI：
10.1093/cercor/bhaa284
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发表时间：
2021-01-05
期刊：
影响因子：
--
通讯作者：
Nasr S
中科院分区：
文献类型：
--
作者：
Tootell RBH;Nasr S
在人类中，视觉刺激可以在巨大的光水平范围内被感知。有证据表明，不同的神经机制处理这个范围的不同细分。例如，在视网膜中，在非常低（暗适应）光水平下呈现的刺激激活视杆光感受器，而视锥光感受器在较高（明适应）光水平下相对更多地被激活。类似地，不同的视网膜神经节细胞被暗视刺激与明视刺激激活。然而，在大脑中，暗视与明视信息是否：1）在不同的通道中处理，或2）神经融合，仍然是未知的。使用高分辨率功能磁共振成像在7 T，我们证实了第一个假设。我们首先基于对运动与颜色的明视选择性，分别在区域V2、V3和V4内定位厚型柱与薄型柱。接下来，我们发现暗视刺激选择性地激活V2和V3（重叠和振幅测量）和V4（基于重叠）中的厚（与薄相比）型列。最后，我们发现更强的静息状态功能连接暗点为主的区域MT厚（相比薄）型列在V2，V3和V4区。我们的结论是，暗视刺激处理部分隔离的平行流，强调magnocellular的影响，从视网膜到中间阶段的视觉皮层。
In humans, visual stimuli can be perceived across an enormous range of light levels. Evidence suggests that different neural mechanisms process different subdivisions of this range. For instance, in the retina, stimuli presented at very low (scotopic) light levels activate rod photoreceptors, whereas cone photoreceptors are activated relatively more at higher (photopic) light levels. Similarly, different retinal ganglion cells are activated by scotopic versus photopic stimuli. However, in the brain, it remains unknown whether scotopic versus photopic information is: 1) processed in distinct channels, or 2) neurally merged. Using high-resolution functional magnetic resonance imaging at 7 T, we confirmed the first hypothesis. We first localized thick versus thin-type columns within areas V2, V3, and V4, based on photopic selectivity to motion versus color, respectively. Next, we found that scotopic stimuli selectively activated thick- (compared to thin-) type columns in V2 and V3 (in measurements of both overlap and amplitude) and V4 (based on overlap). Finally, we found stronger resting-state functional connections between scotopically dominated area MT with thick- (compared to thin-) type columns in areas V2, V3, and V4. We conclude that scotopic stimuli are processed in partially segregated parallel streams, emphasizing magnocellular influence, from retina through middle stages of visual cortex.
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影响因子：
3.3
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