The microbiota and chronic kidney diseases: a double-edged sword.
The microbiota and chronic kidney diseases: a double-edged sword.
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DOI：
10.1038/cti.2016.36
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发表时间：
2016-06
影响因子：
5.8
通讯作者：
中科院分区：
文献类型：
--
作者：
最近关于微生物群在许多炎症过程中的影响的发现为治疗疾病提供了新的途径。现在，人们可能会假设，大量疾病的起源与肠道微生物群的健康及其与上皮和免疫系统之间微妙而复杂的界面有关。例如，饮食的“西方化”与肠道菌群的改变有关。这种改变已被发现与糖尿病和高血压发病率的增加直接相关，而糖尿病和高血压是慢性肾脏疾病（CKDs）的主要原因，而慢性肾脏疾病（CKDs）的估计患病率也很高。事实上，已经出现的数据表明，肾脏疾病的进展与微生物群的组成密切相关。ckd期间肠道微生物群多样性的改变不仅有可能加剧肾损伤，而且可能导致相关合并症的发展，如心血管疾病和胰岛素抵抗。在这篇综述中，我们讨论了如何通过改变肠道屏障和随后的免疫系统激活的生态失调加剧CKD的进展，反之亦然，CKD如何改变肠道微生物群的多样性和丰度。
Recent findings regarding the influence of the microbiota in many inflammatory processes have provided a new way to treat diseases. Now, one may hypothesize that the origin of a plethora of diseases is related to the health of the gut microbiota and its delicate, although complex, interface with the epithelial and immune systems. The ‘westernization' of diets, for example, is associated with alterations in the gut microbiota. Such alterations have been found to correlate directly with the increased incidence of diabetes and hypertension, the main causes of chronic kidney diseases (CKDs), which, in turn, have a high estimated prevalence. Indeed, data have arisen showing that the progression of kidney diseases is strictly related to the composition of the microbiota. Alterations in the gut microbiota diversity during CKDs do not only have the potential to exacerbate renal injury but may also contribute to the development of associated comorbidities, such as cardiovascular diseases and insulin resistance. In this review, we discuss how dysbiosis through alterations in the gut barrier and the consequent activation of immune system could intensify the progression of CKD and vice versa, how CKDs can modify the gut microbiota diversity and abundance.
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影响因子：
3.7
作者：
Castoldi A;Braga TT;Correa-Costa M;Aguiar CF;Bassi ÊJ;Correa-Silva R;Elias RM;Salvador F;Moraes-Vieira PM;Cenedeze MA;Reis MA;Hiyane MI;Pacheco-Silva Á;Gonçalves GM;Saraiva Câmara NO
通讯作者：
Saraiva Câmara NO
影响因子：
17.1
作者：
Arrieta, Marie-Claire;Stiemsma, Leah T.;Finlay, B. Brett
通讯作者：
Finlay, B. Brett
DOI：
10.1097/01.asn.0000022017.96399.b2
发表时间：
2002-07-01
影响因子：
13.6
作者：
Enomoto, A;Takeda, M;Niwa, T
通讯作者：
Niwa, T
影响因子：
56.9
作者：
Gill, Steven R.;Pop, Mihai;Nelson, Karen E.
通讯作者：
Nelson, Karen E.
通过饮食纤维对人肠道微生物群的调节发生在物种水平上。
影响因子：
5.4
作者：
Chung WS;Walker AW;Louis P;Parkhill J;Vermeiren J;Bosscher D;Duncan SH;Flint HJ
通讯作者：
Flint HJ