Bile acids increase the activity of the epithelial Na+ channel
Bile acids increase the activity of the epithelial Na+ channel
复制标题
胆汁酸增加上皮钠离子通道的活性
DOI：
10.1007/s00424-013-1403-0
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Gründer
中科院分区：
文献类型：
--
作者：
Wiemuth;Lefevre;Heidtmann;Gründer
上皮Na+通道(ENaC)是包括远端肾单位和远端结肠在内的多种上皮细胞吸收Na+的关键调节因子。ENAC是一种结构性的活性通道，但其活性受多种机制的调节。这些包括蛋白水解性激活、泛素化和细胞表面表达、磷酸化、细胞内Na+浓度和剪切力。ENAC与胆汁酸敏感离子通道(BASIC)有关，BASIC是一种在胆管上皮细胞表达的通道。碱性被毫摩尔浓度的细胞外胆汁酸激活。胆汁酸是由肝脏合成的，并分泌到十二指肠以帮助脂肪分解。大部分分泌的胆汁酸被回肠吸收并再循环到肝脏，但一小部分通过结肠并被排泄。胆汁酸可以影响包括结肠在内的肠道中的离子运输过程。在这项研究中，我们发现大鼠胆汁中存在的各种胆汁酸可以有效且可逆地增加Xenopus卵母细胞表达的大鼠ENaC的活性，这表明胆汁酸是ENaC活性的天然调节剂。
The epithelial Na+channel (ENaC) is a key regulator of Na+absorption in various epithelia including the distal nephron and the distal colon. ENaC is a constitutively active channel, but its activity is modulated by a number of mechanisms. These include proteolytic activation, ubiquitination and cell surface expression, phosphorylation, intracellular Na+concentration, and shear stress. ENaC is related to the bile acid-sensitive ion channel (BASIC), a channel that is expressed in the epithelial cells of bile ducts. BASIC is activated by millimolar concentrations of extracellular bile acids. Bile acids are synthesized by the liver and secreted into the duodenum to aid lipolysis. A large fraction of the secreted bile acids is absorbed by the ileum and recirculated into the liver, but a small fraction passes the colon and is excreted. Bile acids can influence the ion transport processes in the intestinal tract including the colon. In this study, we show that various bile acids present in rat bile potently and reversibly increase the activity of rat ENaC expressed inXenopusoocytes, suggesting that bile acids are natural modulators of ENaC activity.
登录
查看更多内容
影响因子：
3.6
作者：
Wiemuth, Dominik;Gruender, Stefan
通讯作者：
Gruender, Stefan
影响因子：
29.4
作者：
Hagop S. Mekhjian;Sidney F. Phillips
通讯作者：
Sidney F. Phillips
影响因子：
64.8
作者：
LINGUEGLIA, E;CHAMPIGNY, G;BARBRY, P
通讯作者：
BARBRY, P
影响因子：
5.5
作者：
Balut, C;Steels, P;Jans, D
通讯作者：
Jans, D
胆汁酸对青蛙皮肤阿米洛利敏感钠通道激活的影响
影响因子：
2.7
作者：
M. Lima;H.C. Ferreira;KT Ferreira
通讯作者：
KT Ferreira