Planar cell polarity-dependent and independent functions in the emergence of tissue-scale hair follicle patterns.
Planar cell polarity-dependent and independent functions in the emergence of tissue-scale hair follicle patterns.
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DOI：
10.1016/j.ydbio.2017.06.003
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发表时间：
2017-08-01
影响因子：
2.7
通讯作者：
Devenport D
中科院分区：
文献类型：
--
作者：
Cetera M;Leybova L;Woo FW;Deans M;Devenport D
哺乳动物表皮的毛囊显示局部有序和全局排列，这是一种由核心平面细胞极性（PCP）途径指导的复杂模式。在这里，我们解决的贡献核心PCP基因，货车高夫样和卷曲，建立，局部细化，和全球秩序的胚胎和出生后的毛囊。我们发现，与Fz6突变体类似，Vangl2突变体的无序毛发模式随着时间的推移而得到改善并最终得到纠正。在这两个突变体中，我们发现，组织水平的重新定位发生通过局部协调卵泡旋转在刻板的位置。引人注目的是，Vangl2和Fz6突变体卵泡共同旋转相反的方向，这表明冗余的核心PCP信号有助于他们的定向重新排列。一致地，在Vangl1和Vangl2基因的条件性消融后，整体卵泡排列没有恢复。相反，空间上不同的模式的螺纹和交叉出现，并坚持即使在一个完整的周期毛囊再生。因此，毛囊局部细化成更高阶的模式可以独立于核心PCP系统发生，然而，它们与身体轴的全局对齐需要PCP在整个形态发生、生长和再生过程中发挥作用。
Hair follicles of the mammalian epidermis display local order and global alignment, a complex pattern instructed by the core planar cell polarity (PCP) pathway. Here we address the contributions of core PCP genes, Van Gogh-like and Frizzled, to the establishment, local refinement, and global order of embryonic and postnatal hair follicles. We find that, similar to Fz6 mutants, the disordered hair patterns of Vangl2 mutants are refined over time and eventually corrected. In both mutants, we find that tissue-level reorientation occurs through locally coordinated follicle rotation at stereotyped locations. Strikingly, Vangl2 and Fz6 mutant follicles collectively rotate with opposing directionalities, suggesting that redundant core PCP signals contribute to their directed realignment. Consistently, global follicle alignment is not restored upon conditional ablation of both Vangl1 and Vangl2 genes. Instead, spatially distinct patterns of whorls and crosses emerge and persist even after a complete cycle of hair follicle regeneration. Thus, local refinement of hair follicles into higher order patterns can occur independently of the core PCP system, however, their global alignment with the body axes requires PCP function throughout morphogenesis, growth and regeneration.
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影响因子：
21.3
作者：
通讯作者：
--
影响因子：
16.6
作者：
Cetera M;Ramirez-San Juan GR;Oakes PW;Lewellyn L;Fairchild MJ;Tanentzapf G;Gardel ML;Horne-Badovinac S
通讯作者：
Horne-Badovinac S
DOI：
10.1073/pnas.0402802101
发表时间：
2004-06-22
影响因子：
11.1
作者：
Guo, N;Hawkins, C;Nathans, J
通讯作者：
Nathans, J
影响因子：
4
作者：
Alonso, L;Fuchs, E
通讯作者：
Fuchs, E
影响因子：
21.3
作者：
Devenport, Danelle;Fuchs, Elaine
通讯作者：
Fuchs, Elaine