The androgen-dependent mouse seminal vesicle secretory protein IV: characterization and complementary deoxyribonucleic acid cloning.
The androgen-dependent mouse seminal vesicle secretory protein IV: characterization and complementary deoxyribonucleic acid cloning.
复制标题
雄激素依赖性小鼠精囊分泌蛋白 IV：表征和互补脱氧核糖核酸克隆。
作者：
Y. H. Chen;B. Pentecost;J. Mclachlan;C. Teng
分离了小鼠精囊分泌蛋白IV，并克隆了编码其mRNA的cDNA并进行了序列测定。556个核苷酸编码16个氨基酸的信号肽和92个氨基酸的成熟蛋白。小鼠和大鼠SVS IV的cDNA序列具有很高的同源性，前导肽和3 '端非编码区的同源性分别为92%和85%。其他区域同源性为前12个氨基酸86%，后35个氨基酸68.5%，中间44个氨基酸40%。小鼠SVS IV mRNA的表达受雄激素的调控。给去势小鼠施用睾酮导致在96小时的激素处理中mRNA水平诱导至成熟雄性的50%。睾酮注射后蛋白质的分泌遵循类似的模式。
Seminal vesicle secretory protein IV of a mouse has been isolated, and the cDNA coding for its mRNA has been cloned and sequenced. The 556-nucleotides encode 16 amino acid signal peptides and 92 residues of mature protein. Considerable homology between mouse and rat SVS IV cDNA was found. In the leader peptide and 3'-noncoding region there is 92% and 85% homology, respectively. The other regional homologies are 86% for the first 12, 68.5% for the last 35, and 40% for the middle 44 amino acids. The expression of mouse SVS IV mRNA is under the control of androgen. Administration of testosterone to castrated mice resulted in induction of the mRNA level to 50% of the mature male in 96 h of hormone treatment. Secretion of the protein after testosterone injection follows a similar pattern.
大鼠精囊分泌的主要大多肽分析：SVS I、II、III。
影响因子：
3.6
作者：
Wagner,CL;Kistler,WS
通讯作者：
Kistler,WS