Multi-stage delivery nano-particle systems for therapeutic applications.
Multi-stage delivery nano-particle systems for therapeutic applications.
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DOI：
10.1016/j.bbagen.2010.05.004
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发表时间：
2011-03
影响因子：
3
通讯作者：
Ferrari, Mauro
中科院分区：
文献类型：
--
作者：
Serda, Rita E.;Godin, Biana;Blanco, Elvin;Chiappini, Ciro;Ferrari, Mauro
药物分子到达病理损伤的艰巨任务推动了纳米医学的快速发展。纳米载体的逐步进化导致了多阶段输送系统的发展，目的是克服纳米载体在前往目标地点的旅途中遇到的许多障碍。本文综述了硅基药物载体在癌症治疗和成像方面的主要研究成果。在合理设计的基础上，成熟的硅技术已被用于制造具有特定形状、尺寸和孔隙率的纳米矢量。这些载体是包含多个纳米组件的多阶段递送系统的一部分，每个纳米组件旨在实现特定任务，共同目标是现场定向递送治疗药物。半球形和盘状硅微粒在血液中的边集作用优于球形微粒，不同形状和大小的微粒在体内具有独特的分布。硅微粒的细胞黏附和内化受微粒形状和表面电荷的影响，后者决定了血清调理素的结合。基于体外细胞研究，内皮细胞和巨噬细胞对多孔硅微粒的内化与细胞形态、细胞内转运、有丝分裂、细胞周期进程、细胞因子释放和细胞活力相一致。体内研究支持脂质体包裹的siRNA在多阶段系统中比游离纳米粒具有更好的治疗效果。
The daunting task for drug molecules to reach pathological lesions has fueled rapid advances in Nanomedicine. The progressive evolution of nanovectors has led to the development of multi-stage delivery systems aimed at overcoming the numerous obstacles encountered by nanovectors on their journey to the target site. This review summarizes major findings with respect to silicon-based drug delivery vectors for cancer therapeutics and imaging. Based on rational design, well established silicon technologies have been adapted for the fabrication of nanovectors with specific shapes, sizes, and porosities. These vectors are part of a multi-stage delivery system that contains multiple nano-components, each designed to achieve a specific task with the common goal of site-directed delivery of therapeutics. Quasi-hemispherical and discoidal silicon microparticles are superior to spherical particles with respect to margination in the blood, with particles of different shapes and sizes having unique distributions in vivo. Cellular adhesion and internalization of silicon microparticles is influenced by microparticle shape and surface charge, with the latter dictating binding of serum opsonins. Based on in vitro cell studies, the internalization of porous silicon microparticles by endothelial cells and macrophages is compatible with cellular morphology, intracellular trafficking, mitosis, cell cycle progression, cytokine release, and cell viability. In vivo studies support superior therapeutic efficacy of liposomal encapsulated siRNA when delivered in multi-stage systems compared to free nanoparticles.
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DOI：
10.1073/pnas.2232479100
发表时间：
2003-11-11
影响因子：
11.1
作者：
Hirsch, LR;Stafford, RJ;West, JL
通讯作者：
West, JL
影响因子：
14
作者：
Decuzzi, Paolo;Ferrari, Mauro
通讯作者：
Ferrari, Mauro
影响因子：
2.9
作者：
Boujday, Souhir;Blanchard, Juliette;Proust, Anna
通讯作者：
Proust, Anna
DOI：
10.1002/cphc.200900914
发表时间：
2010-04-06
期刊：
Chemphyschem : a European journal of chemical physics and physical chemistry
影响因子：
--
作者：
Chiappini C;Tasciotti E;Fakhoury JR;Fine D;Pullan L;Wang YC;Fu L;Liu X;Ferrari M
通讯作者：
Ferrari M
影响因子：
56.9
作者：
Hood, JD;Bednarski, M;Cheresh, DA
通讯作者：
Cheresh, DA