Effect of Non-Alcoholic Fatty Liver Disease on Estimated Glomerular Filtration Rate Could Be Dependent on Age.
Effect of Non-Alcoholic Fatty Liver Disease on Estimated Glomerular Filtration Rate Could Be Dependent on Age.
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非酒精性脂肪肝对估计肾小球滤过率的影响可能取决于年龄
DOI：
10.1371/journal.pone.0130614
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Shen Z;Munker S;Luo F;Ma H;Yu C;Li Y
非酒精性脂肪性肝病（NAFLD）和肾功能之间的关联在明显健康的人群中存在差距。本研究旨在评估NAFLD是否与估计的肾小球滤过率（eGFR）水平相关，并了解NAFLD中eGFR的早期变化。在2013年1月至2013年12月在中国浙江大学医学院附属第一医院接受一般健康筛查（包括实验室评估和肝脏超声检查）的表面健康人群中进行了一项横断面研究。本研究纳入了1，193例受试者，平均年龄为48岁。NAFLD患病率为31.3%。NAFLD患者的平均eGFR显著低于对照组（107 ± 19 mL/min/1.73 m2 vs. 113 ± 23 mL/min/1.73 m2，P<0.001）。eGFR与NAFLD相关危险因素的相关分析显示，eGFR水平与某些NAFLD危险因素呈负相关（均P<0.01）。所有受试者根据年龄分为五个阶段。年龄≤ 50岁的NAFLD组3个阶段的平均eGFR水平均低于对照组（P均<0.05），而年龄>50岁的NAFLD组2个阶段的平均eGFR水平与对照组相比均无显著性差异（P均>0.05）。在明显健康的人群中，eGFR水平与NAFLD及其危险因素显著相关。NAFLD对eGFR的影响可能取决于年龄。
There is a gap between the association of non-alcoholic fatty liver disease (NAFLD) and renal function in an apparently healthy population. This study aims to assess whether NAFLD is associated with estimated glomerular filtration rate (eGFR) levels and to understand early changes of eGFR in NAFLD. A cross-sectional study was performed among apparently healthy persons who underwent general health screening including laboratory assessments and hepatic ultrasonography from January 2013 to December 2013 at the First Affiliated Hospital of Zhejiang University, College of Medicine, China. This study included 1,193 subjects with a mean age of 48 years. Prevalence of NAFLD was 31.3%. Mean eGFR was significantly lower in NAFLD than in controls (107 ± 19 mL/min/1.73 m2 vs. 113 ± 23 mL/min/1.73 m2, P<0.001). Correlation analysis between eGFR and NAFLD related risk factors revealed an inverse correlation between eGFR levels and some NAFLD risk factors (all P<0.01). All subjects were classified into five phases according to age. Average eGFR levels of NAFLD were lower than controls in three phases for subjects with ≤ 50 years of age (all P<0.05), while there were no significant differences on average eGFR levels between NAFLD and controls in two phases for subjects with >50 years of age (Both P>0.05). The eGFR level is significantly associated with NAFLD and its risk factors in an apparently healthy population. Effects of NAFLD on eGFR could be dependent on age.
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影响因子：
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作者：
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