Association of proton pump inhibitor and histamine H2-receptor antagonists with restless legs syndrome.
Association of proton pump inhibitor and histamine H2-receptor antagonists with restless legs syndrome.
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DOI：
10.1093/sleep/zsaa220
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发表时间：
2021-04-09
期刊：
影响因子：
5.6
通讯作者：
Page GP
中科院分区：
文献类型：
--
作者：
Earley EJ;Didriksen M;Spencer BR;Kiss JE;Erikstrup C;Pedersen OB;Sørensen E;Burgdorf KS;Kleinman SH;Mast AE;Busch MP;Ullum H;Page GP
不宁腿综合征（RLS）是一种常见的感觉运动障碍，它可以扰乱睡眠，并被认为是由低细胞铁储存部分引起的。质子泵抑制剂（PPI）和组胺H2受体拮抗剂（H2 A）是世界上最常用的药物之一，并显示出导致缺铁的证据。我们对美国（N = 13，403; REDS-III）和丹麦（N = 50，323;丹麦献血者研究，DBDS）的献血者进行了一项病例/非病例观察性研究，这两个国家都有全血细胞计数测量和通过剑桥-霍普金斯RLS问卷完成的RLS评估。在调整年龄、性别、种族、BMI、献血频率、吸烟、激素使用和铁补充剂使用后，PPI/H2 A使用与RLS相关（比值比[OR] = 1.41; 95%置信区间[CI]，1.13-1.76; p = 0.002）（OR = 1.43; CI，1.03-1.95; p = 0.03）和H2A（OR = 1.56; CI，1.10-2.16; p = 0.01）。DBDS与PPI/H2 As（OR = 1.29; CI，1.20-1.40; p < 0.001）和PPI单独给药（OR = 1.27; CI，1.17-1.38; p < 0.001）表现出相似的相关性，但与H2 As单独给药（OR = 1.18; CI，0.92-1.53; p = 0.2）无关。我们没有发现血液铁储存介导这种关联的证据。PPI和可能的H2 A消耗与RLS的关联独立于血铁状态和其他导致RLS风险的因素，这表明需要重新评估PPI/H2 A在RLS特定风险人群中的使用。
Restless legs syndrome (RLS) is a common sensorimotor disorder, which can disrupt sleep and is thought to be caused in part by low cellular iron stores. Proton pump inhibitors (PPI) and histamine H2-receptor antagonists (H2A) are among the most commonly used drugs worldwide and show evidence of causing iron deficiency. We conducted a case/non-case observational study of blood donors in the United States (N = 13,403; REDS-III) and Denmark (N = 50,323; Danish Blood Donor Study, DBDS), both of which had complete blood count measures and a completed RLS assessment via the Cambridge–Hopkins RLS questionnaire. After adjusting for age, sex, race, BMI, blood donation frequency, smoking, hormone use, and iron supplement use, PPI/H2A use was associated with RLS (odds ratio [OR] = 1.41; 95% confidence interval [CI], 1.13–1.76; p = 0.002) in REDS-III for both PPI (OR = 1.43; CI, 1.03–1.95; p = 0.03) and H2A (OR = 1.56; CI, 1.10–2.16; p = 0.01). DBDS exhibited a similar association with PPIs/H2As (OR = 1.29; CI, 1.20–1.40; p < 0.001), and for PPIs alone (OR = 1.27; CI, 1.17–1.38; p < 0.001), but not H2As alone (OR = 1.18; CI, 0.92–1.53; p = 0.2). We found no evidence of blood iron stores mediating this association. The association of PPI, and possibly H2A, consumption with RLS independent of blood iron status and other factors which contribute to RLS risk suggest the need to re-evaluate use of PPI/H2A in populations at particular risk for RLS.
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DOI：
10.1016/s0140-6736(17)31928-1
发表时间：
2017-11-25
期刊：
Lancet (London, England)
影响因子：
--
作者：
Di Angelantonio E;Thompson SG;Kaptoge S;Moore C;Walker M;Armitage J;Ouwehand WH;Roberts DJ;Danesh J;INTERVAL Trial Group
通讯作者：
INTERVAL Trial Group
影响因子：
--
作者：
Allen, RP;Walters, AS;Ferini-Strambi, L
通讯作者：
Ferini-Strambi, L
影响因子：
--
作者：
Dignass A;Farrag K;Stein J
通讯作者：
Stein J
影响因子：
2.8
作者：
Cotter, Paul E;O'Keeffe, Shaun T
通讯作者：
O'Keeffe, Shaun T
影响因子：
4.8
作者：
Allen, Richard P.;Adler, Charles H.;Earley, Christopher J.
通讯作者：
Earley, Christopher J.