Radiation effects on antitumor immune responses: current perspectives and challenges.
Radiation effects on antitumor immune responses: current perspectives and challenges.
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辐射对抗肿瘤免疫反应的影响：当前的观点和挑战。
DOI：
10.1177/1758834017742575
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发表时间：
2018
影响因子：
4.9
通讯作者：
Lecanda F
中科院分区：
文献类型：
--
作者：
Walle T;Martinez Monge R;Cerwenka A;Ajona D;Melero I;Lecanda F
目前，超过50%的癌症患者在治疗、辅助或姑息治疗过程中使用放射治疗(RT)。RT可实现肿瘤生长的良好局部控制，导致DNA损伤，并影响肿瘤血管和免疫系统。以前被认为仅仅是一种免疫抑制治疗，前期和临床观察表明，RT的治疗效果部分是由免疫介导的。在某些情况下，RT与免疫治疗(IT)协同作用，通过不同的机制促进有效的抗肿瘤免疫反应。RT诱导的细胞死亡被认为是免疫原性的，导致肿瘤微环境中淋巴细胞效应功能的调节，促进局部控制。此外，全身免疫反应可以被激发或调节，以施加辐射范围外的影响(所谓的非局域效应)。在这篇综述中，我们讨论了与RT相关的证据以及它对未来设计新的联合治疗的免疫原性的潜力。
Radiotherapy (RT) is currently used in more than 50% of cancer patients during the course of their disease in the curative, adjuvant or palliative setting. RT achieves good local control of tumor growth, conferring DNA damage and impacting tumor vasculature and the immune system. Formerly regarded as a merely immunosuppressive treatment, pre- and clinical observations indicate that the therapeutic effect of RT is partially immune mediated. In some instances, RT synergizes with immunotherapy (IT), through different mechanisms promoting an effective antitumor immune response. Cell death induced by RT is thought to be immunogenic and results in modulation of lymphocyte effector function in the tumor microenvironment promoting local control. Moreover, a systemic immune response can be elicited or modulated to exert effects outside the irradiation field (so called abscopal effects). In this review, we discuss the body of evidence related to RT and its immunogenic potential for the future design of novel combination therapies.
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影响因子：
64.5
作者：
Benci JL;Xu B;Qiu Y;Wu TJ;Dada H;Twyman-Saint Victor C;Cucolo L;Lee DSM;Pauken KE;Huang AC;Gangadhar TC;Amaravadi RK;Schuchter LM;Feldman MD;Ishwaran H;Vonderheide RH;Maity A;Wherry EJ;Minn AJ
通讯作者：
Minn AJ
影响因子：
11.2
作者：
Burnette BC;Liang H;Lee Y;Chlewicki L;Khodarev NN;Weichselbaum RR;Fu YX;Auh SL
通讯作者：
Auh SL
影响因子：
3.7
作者：
Belcaid Z;Phallen JA;Zeng J;See AP;Mathios D;Gottschalk C;Nicholas S;Kellett M;Ruzevick J;Jackson C;Albesiano E;Durham NM;Ye X;Tran PT;Tyler B;Wong JW;Brem H;Pardoll DM;Drake CG;Lim M
通讯作者：
Lim M
影响因子：
50.3
作者：
Ahn, G-One;Brown, J. Martin
通讯作者：
Brown, J. Martin
影响因子：
4.4
作者：
Chakraborty, M;Abrams, SI;Hodge, JW
通讯作者：
Hodge, JW