Interleaved susceptibility-weighted and FLAIR MRI for imaging lesion-penetrating veins in multiple sclerosis.
Interleaved susceptibility-weighted and FLAIR MRI for imaging lesion-penetrating veins in multiple sclerosis.
复制标题
DOI：
10.1002/mrm.27091
复制
发表时间：
2018-09
影响因子：
3.3
通讯作者：
Narayana PA
中科院分区：
文献类型：
--
作者：
Gabr RE;Pednekar AS;Kamali A;Lincoln JA;Nelson FM;Wolinsky JS;Narayana PA
同时成像多发性硬化症的脑部病变和静脉。在3.0T MRI系统上开发了一种交错序列，以同时采集3D T2* 加权（或磁共振加权，SW）和液体衰减反转恢复（FLAIR）图像。计算脉冲序列参数，以最大限度地减少稳态信号扰动，同时保持可接受的图像对比度和扫描时间。15名多发性硬化症患者参加了这项前瞻性研究，并接受了标准的MS成像方案。此外，SW和FLAIR图像分别采集，也以交错方式。将SW和FLAIR图像合并为一个图像，以显示病变和穿通静脉。在交错序列和单独的非交错采集之间比较了白色病变和穿透静脉之间的对比度。实现了FLAIR和SW脉冲序列的交错扫描，产生对齐的图像，并且具有与非交错图像相似的图像对比度。在所有患者中，在组合SW-FLAIR图像上共识别出1076个病变，其中968个病变（90%）具有可见的穿通静脉。与使用单独采集的28.1 ± 13.7相比，交错序列的病变-静脉对比度为32.7 ± 17.9（平均值±标准差）（P<0.001）。证明了磁共振加权成像和FLAIR图像交错采集的可行性。该序列提供自配准图像，并有助于脑部病变中静脉的可视化。
To simultaneously image brain lesions and veins in multiple sclerosis. An interleaved sequence was developed to simultaneously acquire 3D T2*-weighted (or susceptibility-weighted, SW) and fluid-attenuated inversion recovery (FLAIR) images on a 3.0T MRI system. The pulse sequence parameters were calculated to minimize signal perturbation from steady state while maintaining acceptable image contrast and scan time. Fifteen multiple sclerosis patients were enrolled in this prospective study and underwent a standard MS imaging protocol. In addition, SW and FLAIR images were acquired separately and also in an interleaved manner. The SW and FLAIR images were combined into one image to visualize lesions and penetrating veins. The contrast ratios between white matter lesions and penetrating veins were compared between the interleaved sequence and the individual non-interleaved acquisitions. Interleaved scanning of the FLAIR and the SW pulse sequences was achieved, producing aligned images, and with similar image contrast as in the non-interleaved images. A total of 1076 lesions were identified in all patients on the combined SW-FLAIR image, of which 968 lesions (90%) had visible penetrating veins. Lesion-to-vein contrast ratio was 32.7 ± 17.9 (mean ± standard deviation) for the interleaved sequence compared to 28.1 ± 13.7 using the separate acquisitions (P<0.001). The feasibility of interleaved acquisition of susceptibility-weighted and FLAIR images was demonstrated. This sequence provides self-registered images and facilitates the visualization of veins in brain lesions.
登录
查看更多内容
影响因子：
5.4
作者：
Ji, Shihao;Dunson, David;Carin, Lawrence
通讯作者：
Carin, Lawrence
影响因子：
3.3
作者：
Henningsson, Markus;Mens, Giel;Botnar, Rene M.
通讯作者：
Botnar, Rene M.
影响因子：
3.3
作者：
Bilgic, Berkin;Goyal, Vivek K.;Adalsteinsson, Elfar
通讯作者：
Adalsteinsson, Elfar
DOI：
10.1177/1352458517726383
发表时间：
2018-05
期刊：
Multiple sclerosis (Houndmills, Basingstoke, England)
影响因子：
--
作者：
Solomon AJ;Watts R;Ontaneda D;Absinta M;Sati P;Reich DS
通讯作者：
Reich DS
影响因子：
11.2
作者：
Polman CH;Reingold SC;Banwell B;Clanet M;Cohen JA;Filippi M;Fujihara K;Havrdova E;Hutchinson M;Kappos L;Lublin FD;Montalban X;O'Connor P;Sandberg-Wollheim M;Thompson AJ;Waubant E;Weinshenker B;Wolinsky JS
通讯作者：
Wolinsky JS