The Edinburgh Cognitive and Behavioural ALS Screen (ECAS) for Japanese ALS and FTD patients
The Edinburgh Cognitive and Behavioural ALS Screen (ECAS) for Japanese ALS and FTD patients
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针对日本 ALS 和 FTD 患者的爱丁堡认知和行为 ALS 筛查 (ECAS)
DOI：
10.1080/21678421.2020.1801751
复制
发表时间：
2021
影响因子：
2.8
通讯作者：
Nakashima Kenji
中科院分区：
文献类型：
--
作者：
Watanabe Yasuhiro;Ogino Mieko;Ichikawa Hiroo;Hanajima Ritsuko;Nakashima Kenji
肌萎缩侧索硬化症(ALS)患者可能出现类似额颞叶痴呆(FTD)的认知和行为异常。爱丁堡认知和行为ALS屏幕(ECAS)被开发为一种易于管理的认知屏幕，用于检测这些症状。本研究的目的是开发和验证日本版的ECAs。方法在这项单中心观察性研究中，35名ALS患者和28名健康对照被纳入研究。ALS组中有3名患者符合行为变异型FTD(ALS-FTD)标准，其余患者被归类为ALS而无FTD。参与者接受了日语版的ECAS。ALS患者还接受了蒙特利尔认知评估、正面评估组合、修订后的ALS功能评定量表和呼吸功能测试。人口学和疾病特征(如性别、检查年龄和教育年限)也被记录下来。结果在日本适应中，内部一致性和与一般认知筛查的相关性是足够的。行政职能是最受影响的ECAS领域，其次是流利性和语言。与对照组相比，无FTD的ALS患者在ECAS ALS特异性功能方面得分较低，但在ALS非特异性功能方面得分较低。同时，ALS-FTD患者在ECAS ALS特异性和非特异性ALS功能上均显着低下。此外，日语版ECAS得分与受教育年限呈正相关，与发病年龄呈负相关。结论日文版ECAS是一种有效的筛查工具，可用于ALS患者多种认知功能障碍的筛查。
ObjectiveAmyotrophic lateral sclerosis (ALS) patients might present with cognitive and behavioural abnormalities resembling frontotemporal dementia (FTD). The Edinburgh Cognitive and Behavioural ALS Screen (ECAS) was developed as an easy to administer cognitive screen for detecting these symptoms. The aim of the present study was to develop and validate a Japanese version of the ECAS.MethodsIn this single centre observational study, 35 ALS patients and 28 healthy controls were enrolled. Three patients in the ALS group fulfilled the criteria for behavioural variant FTD (ALS-FTD) and the rest were grouped as ALS without FTD. Participants were subjected to the Japanese version of the ECAS. ALS patients were also subjected to the Montreal Cognitive Assessment, Frontal Assessment Battery, ALS Functional Rating Scale-Revised, and respiratory function testing. Demographic and disease characteristics (e.g., sex, age at examination, and years of education) were also recorded.ResultsInternal consistency and correlations with general cognitive screenings were sufficient in the Japanese adaptation. Executive functions were the most commonly affected ECAS domain, followed by fluency and language. Compared to control subjects, ALS patients without FTD had low scores in the ECAS ALS-specific functions but not in ALS-nonspecific functions. Meanwhile ALS-FTD patients markedly underperformed both in the ECAS ALS-specific and ALS-nonspecific functions. Furthermore, the Japanese ECAS score correlated positively with years of education and negatively with age at onset.ConclusionThe Japanese version of the ECAS is a valid and useful screening tool to identify multiple types of cognitive impairment in ALS patients.
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DOI：
10.3109/21678421.2016.1162814
发表时间：
2016-07-01
影响因子：
2.8
作者：
Loose, Markus;Burkhardt, Christian;Lule, Dorothee
通讯作者：
Lule, Dorothee
ALS-FTD-Q
影响因子：
9.9
作者：
MD Joost Raaphorst;MD Emma Beeldman;PhD Ben Schmand;MSc Joris Berkhout;W. Linssen;PhD Leonard H. van den Berg;PhD Yolande A. Pijnenburg;P. H. F. Md;MD Janneke G. Weikamp;MSc H. Jurgen Schelhaas;P. J. M. Md;MD John C. van Swieten;PhD Marianne de Visser;PhD Rob J. de Haan
通讯作者：
PhD Rob J. de Haan
影响因子：
11
作者：
Phukan, Julie;Elamin, Marwa;Hardiman, Orla
通讯作者：
Hardiman, Orla
DOI：
10.1080/21678421.2016.1249887
发表时间：
2017-02-01
影响因子：
2.8
作者：
Pinto-Grau, Marta;Burke, Tom;Pender, Niall
通讯作者：
Pender, Niall
DOI：
10.1016/j.bbrc.2006.10.093
发表时间：
2006-12-22
影响因子：
3.1
作者：
Arai, Tetsuaki;Hasegawa, Masato;Oda, Tatsuro
通讯作者：
Oda, Tatsuro