Circulating osteocalcin level is associated with improved glucose tolerance, insulin secretion and sensitivity independent of the plasma adiponectin level.
Circulating osteocalcin level is associated with improved glucose tolerance, insulin secretion and sensitivity independent of the plasma adiponectin level.
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DOI：
10.1007/s00198-011-1679-x
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发表时间：
2012-04
影响因子：
4
通讯作者：
Chung, H-Y.
中科院分区：
文献类型：
--
作者：
Hwang, Y-C.;Jeong, I-K.;Ahn, K-J.;Chung, H-Y.
与动物研究结果一致的是，血浆骨钙素水平与糖耐量、胰岛素分泌和敏感性的改善呈正相关。此外，血浆骨钙素水平与糖尿病的发生发展呈负相关；然而，在人类中，血浆脂联素水平可能不参与骨钙素介导的能量代谢。最近的动物研究表明，骨钙素在骨骼和能量代谢之间存在串扰。这项研究的目的是确定骨钙素是否与人类糖耐量、胰岛素分泌和敏感性的改善有关，以及这种联系是否依赖于人类血浆脂联素水平。425名受试者，年龄19-82岁，平均53岁。确定了口服葡萄糖耐量试验(OGTT)和基于OGTT的方法，这些方法针对正常血糖钳夹进行了验证。测定总骨钙素、瘦素和总脂联素水平。血浆总骨钙素水平在正常糖耐量组、糖尿病前期组和糖尿病组之间有显著差异。血糖水平和稳态模型评估的胰岛素抵抗值与骨钙素水平呈负相关，基于OGTT的胰岛素分泌(HOMA-B%，倾向指数)和胰岛素敏感性指数(Stumvoll‘s指数和OGIS指数)随骨钙素水平的增加而增加。虽然血浆脂联素水平与骨钙素水平呈正相关，但调整血浆脂联素水平后，血浆骨钙素水平与糖耐量、胰岛素分泌和敏感性指数之间的相关性没有变化。多元Logistic回归分析显示，血浆骨钙素水平与2型糖尿病的发生呈负相关，与年龄、性别、体重指数、空腹血糖和血浆脂联素水平无关。循环中的骨钙素水平与人类糖耐量、胰岛素分泌和敏感性的改善有关，不依赖于血浆脂联素水平。
In agreement with the results of animal studies, the plasma osteocalcin level is positively associated with improved glucose tolerance and insulin secretion and sensitivity. In addition, the plasma osteocalcin level is inversely associated with the development of diabetes; however, the plasma adiponectin level may not be involved in osteocalcin-mediated energy metabolism in humans. Recent animal studies have suggested crosstalk between bone and energy metabolism through osteocalcin. The aims of this study were to determine whether or not osteocalcin is associated with the improved glucose tolerance and insulin secretion and sensitivity, and whether or not the association is dependent on the plasma adiponectin level in humans. Four hundred twenty-five subjects, 19–82 years of age (mean age, 53 years), were enrolled. An oral glucose tolerance test (OGTT) and OGTT-based methods that were validated against the euglycemic clamp were determined. Total osteocalcin, leptin, and total adiponectin levels were measured. The plasma levels of total osteocalcin were significantly different between the normal glucose tolerance, pre-diabetes, and diabetes groups. The glucose levels and homeostasis model assessment insulin resistance values varied inversely with the osteocalcin tertiles, and OGTT-based insulin secretion (HOMA-B%, disposition index) and insulin sensitivity indices (Stumvoll’s and OGIS indices) were increased with the tertiles. Although the plasma adiponectin level was positively correlated with the osteocalcin level, no changes in the association were noted between the plasma osteocalcin level and the glucose tolerance or insulin secretion and sensitivity indices after adjustment for the plasma adiponectin level. Based on multiple logistic regression analysis, the plasma osteocalcin level was inversely associated with the development of type 2 diabetes mellitus independent of age, gender, body mass index, and fasting plasma glucose and plasma adiponectin levels. Circulating osteocalcin level is associated with improved glucose tolerance and insulin secretion and sensitivity independent of the plasma adiponectin level in humans.
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影响因子：
64.5
作者：
Ferron M;Wei J;Yoshizawa T;Del Fattore A;DePinho RA;Teti A;Ducy P;Karsenty G
通讯作者：
Karsenty G
影响因子：
16.2
作者：
Stumvoll, M;Mitrakou, A;Gerich, J
通讯作者：
Gerich, J
影响因子：
64.5
作者：
Lee, Na Kyung;Sowa, Hideaki;Karsenty, Gerard
通讯作者：
Karsenty, Gerard
影响因子：
4.1
作者：
Gundberg, CM;Looker, AC;Calvo, MS
通讯作者：
Calvo, MS
影响因子：
5.8
作者：
Pittas, Anastassios G.;Harris, Susan S.;Dawson-Hughes, Bess
通讯作者：
Dawson-Hughes, Bess