Defective natural immunity: an early manifestation of human immunodeficiency virus infection.
Defective natural immunity: an early manifestation of human immunodeficiency virus infection.
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DOI：
10.1084/jem.182.3.789
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发表时间：
1995-09-01
影响因子：
15.3
通讯作者：
Pedersen, Bente Klarlund
中科院分区：
文献类型：
--
作者：
Ullum, Henrik;Gotzsche, Peter C.;Victor, Jette;Dickmeiss, Ebbe;Skinhoj, Peter;Pedersen, Bente Klarlund
自然杀伤（NK）细胞和淋巴因子激活的杀伤（LAK）细胞介导的细胞毒性在宿主防御病毒感染中可能具有重要意义。这项研究包括347例感染人类免疫缺陷综合征病毒（HIV）1型的患者和110名对照。NK细胞活性，无论是未经刺激或刺激干扰素-α（IFN-α）或白细胞介素-2（IL-2），和LAK细胞活性被抑制的患者，但NK/LAK细胞活性没有差异艾滋病患者和非艾滋病患者。然而，与无症状患者（CDCII+III）相比，具有HIV疾病症状的患者（CDCIV）中IFN-α刺激的NK细胞活性和LAK细胞活性降低。当数据进行多元线性回归分析，CD 4+细胞的百分比有积极的影响，这两个参数在没有艾滋病的患者，而CD 4+细胞的百分比没有显着的影响，在这些患者的非刺激和IL-2刺激的NK细胞活性。在对照组和AIDS患者中，CD 4+细胞百分比在多线性模型中对NK/LAK细胞活性没有影响。与对照组相比，患者的CD 16+细胞总数较低，而CD 16+、CD 56+和CD 16 + CD 56+的百分比正常或升高。因此，NK细胞亚群的减少并没有导致体外NK/LAK细胞活性的降低。它的结论是，自然免疫抑制HIV血清阳性患者主要是因为NK/LAK细胞的质量缺陷。这种定性缺陷包括对IFN-α的反应性降低，这是渐进的，直到症状发作，并可能与CD 4+细胞的损失。
Cytotoxicity mediated by natural killer (NK) and lymphokine-activated killer (LAK) cells may be of significance in host defense against viral infections. This study included 347 patients infected with human immunodeficiency syndrome virus (HIV) type 1 and 110 controls. The NK cell activity, either unstimulated or stimulated with interferon-alpha (IFN-alpha) or interleukin-2 (IL-2), and the LAK cell activity were suppressed in patients, but the NK/LAK cell activity did not differ between patients with AIDS and patients without AIDS. However, the IFN- alpha-stimulated NK cell activity and LAK cell activity were reduced in patients with symptoms of HIV disease (CDCIV) when compared with asymptomatic patients (CDCII+III). When the data were analyzed by multiple linear regression, the percentage of CD4+ cells had a positive effect on these two parameters in patients without AIDS, whereas the percentage of CD4+ cells had no significant effect on unstimulated and IL-2-stimulated NK cell activity in these patients. In controls and AIDS patients, the percentage of CD4+ cells had no effect on NK/LAK cell activity in multiple linear models. The total number of CD16+ cells was low in patients compared to controls, whereas the percentages of CD16+, CD56+, and CD16+CD56+ were either normal or elevated. Therefore, the decrease in NK cell subpopulations did not contribute to the observed depression in NK/LAK cell activity in vitro. It is concluded that natural immunity is suppressed in HIV-seropositive patients primarily because of a qualitative defect of the NK/LAK cells. This qualitative defect includes a reduced responsiveness to IFN-alpha, which is progressive until the onset of symptoms, and possibly related to the loss of CD4+ cells.
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影响因子：
56.9
作者：
FAUCI, AS
通讯作者：
FAUCI, AS
影响因子：
3.8
作者：
GRYLLIS, C;WAINBERG, MA;BRENNER, B
通讯作者：
BRENNER, B
影响因子：
9.1
作者：
PLAEGERMARSHALL, S;SPINA, CA;BEALL, G
通讯作者：
BEALL, G
DOI：
10.1016/0167-5699(90)90070-p
发表时间：
1990-05-01
期刊：
IMMUNOLOGY TODAY
影响因子：
--
作者：
ROSENBERG, ZF;FAUCI, AS
通讯作者：
FAUCI, AS
影响因子：
5.4
作者：
CHEHIMI, J;BANDYOPADHYAY, S;STARR, SE
通讯作者：
STARR, SE