Improving cytomegalovirus-specific T cell reconstitution after haploidentical stem cell transplantation.
Improving cytomegalovirus-specific T cell reconstitution after haploidentical stem cell transplantation.
复制标题
改善单倍相合干细胞移植后巨细胞病毒特异性 T 细胞重建
DOI：
10.1155/2014/631951
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发表时间：
2014
影响因子：
4.1
通讯作者：
Huang XJ
中科院分区：
文献类型：
--
作者：
Luo XH;Chang YJ;Huang XJ
巨细胞病毒（CMV）感染和免疫重建延迟（IR）是影响单倍相合造血干细胞移植（haplo-SCT）成功的严重障碍。CMV特异性IR根据患者是否接受操作/未操作移植物或清髓性/降低强度预处理而变化。CMV感染通常发生在T细胞及其亚群的IR受损之后。在这里，我们讨论的因素影响IR的基础上，目前可用的证据。供体T细胞的连续转移，以改善CMV特异性IR进行了讨论。应该选择来自CMV阳性供体的移植物移植到CMV阳性受体（D+/R+），因为这将导致比来自CMV阴性供体（D-/R+）的移植物更好的IR。干细胞来源和供体年龄是其他重要因素。还应考虑移植后并发症，包括移植物抗宿主病和CMV感染，以及相关治疗。不同程度的HLA差异和预处理方案的影响更有争议。由于这些因素和策略中的许多都被认为是在单倍-SCT的设置，预计单倍-SCT将继续推进，进一步扩大我们对IR和CMV感染的理解。
Cytomegalovirus (CMV) infection and delayed immune reconstitution (IR) remain serious obstacles for successful haploidentical stem cell transplantation (haplo-SCT). CMV-specific IR varied according to whether patients received manipulated/unmanipulated grafts or myeloablative/reduced intensity conditioning. CMV infection commonly occurs following impaired IR of T cell and its subsets. Here, we discuss the factors that influence IR based on currently available evidence. Adoptive transfer of donor T cells to improve CMV-specific IR is discussed. One should choose grafts from CMV-positive donors for transplant into CMV-positive recipients (D+/R+) because this will result in better IR than would grafts from CMV-negative donors (D−/R+). Stem cell source and donor age are other important factors. Posttransplant complications, including graft-versus-host disease and CMV infection, as well as their associated treatments, should also be considered. The effects of varying degrees of HLA disparity and conditioning regimens are more controversial. As many of these factors and strategies are considered in the setting of haplo-SCT, it is anticipated that haplo-SCT will continue to advance, further expanding our understanding of IR and CMV infection.
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DOI：
10.1196/annals.1321.009
发表时间：
2004-01-01
期刊：
GLUCOCORTICOID ACTION: BASIC AND CLINICAL IMPLICATIONS
影响因子：
--
作者：
Franchimont, D
通讯作者：
Franchimont, D
影响因子：
45.3
作者：
Aversa, F;Terenzi, A;Martelli, MF
通讯作者：
Martelli, MF
影响因子：
2.6
作者：
Borchers, S.;Luther, S.;Mischak-Weissinger, E.
通讯作者：
Mischak-Weissinger, E.
影响因子：
4.3
作者：
Azevedo, Rita I.;Soares, Maria V. D.;Sousa, Ana E.
通讯作者：
Sousa, Ana E.
影响因子：
4.5
作者：
Hoegh-Petersen, Mette;Roa, Lina;Storek, Jan
通讯作者：
Storek, Jan