A "FOXO" in sight: targeting Foxo proteins from conception to cancer.
A "FOXO" in sight: targeting Foxo proteins from conception to cancer.
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DOI：
10.1002/med.20139
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发表时间：
2009-05
影响因子：
13.3
通讯作者：
Hou, Jinling
中科院分区：
文献类型：
--
作者：
Maiese, Kenneth;Chong, Zhao Zhong;Shang, Yan Chen;Hou, Jinling
多种疾病实体的成功治疗可以在很大程度上依赖于阐明控制细胞增殖、代谢、存活和炎症的复杂关系的能力。在这里，我们讨论的治疗潜力的哺乳动物叉头转录因子主要在O类，FoxO1，FoxO3，FoxO4和FoxO6，发挥了重要作用，在正常的细胞功能，以及在进行性疾病。这些转录因子与几种信号转导途径整合，如Wnt蛋白，其可以调节广泛的细胞过程，包括干细胞增殖，衰老和恶性肿瘤。FoxO转录因子是针对人类癌症的策略的有吸引力的考虑因素，因为它们具有促凋亡作用和导致细胞周期停滞的能力。然而，FoxO蛋白可能与不育、细胞变性和不受抑制的细胞增殖有关。随着我们对这种新型蛋白质家族的了解不断发展，FoxO家族的潜在临床应用应该会提高我们限制疾病进展而不影响临床的能力。
The successful treatment for multiple disease entities can rest heavily upon the ability to elucidate the intricate relationships that govern cellular proliferation, metabolism, survival, and inflammation. Here we discuss the therapeutic potential of the mammalian forkhead transcription factors predominantly in the O class, FoxO1, FoxO3, FoxO4, and FoxO6, which play a significant role during normal cellular function as well as during progressive disease. These transcription factors are integrated with several signal transduction pathways, such as Wnt proteins, that can regulate a broad array of cellular process that include stem cell proliferation, aging, and malignancy. FoxO transcription factors are attractive considerations for strategies directed against human cancer in light of their pro-apoptotic effects and ability to lead to cell cycle arrest. Yet, FoxO proteins can be associated with infertility, cellular degeneration, and unchecked cellular proliferation. As our knowledge continues to develop for this novel family of proteins, potential clinical applications for the FoxO family should heighten our ability to limit disease progression without clinical compromise.
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