NRAP-1 Is a Presynaptically Released NMDA Receptor Auxiliary Protein that Modifies Synaptic Strength.
NRAP-1 Is a Presynaptically Released NMDA Receptor Auxiliary Protein that Modifies Synaptic Strength.
复制标题
DOI：
10.1016/j.neuron.2017.11.019
复制
发表时间：
2017-12-20
期刊：
影响因子：
16.2
通讯作者：
Maricq AV
中科院分区：
文献类型：
--
作者：
Lei N;Mellem JE;Brockie PJ;Madsen DM;Maricq AV
NMDA receptors (NMDARs) are a subtype of postsynaptic ionotropic glutamate receptors that function as molecular coincidence detectors, have critical roles in models of learning, and are associated with a variety of neurological and psychiatric disorders. To date, no auxiliary proteins that modify NMDARs have been identified. Here, we report the identification of NRAP-1, an auxiliary protein in C. elegans that modulates NMDAR function. NMDAR-mediated currents were eliminated in nrap-1 mutants, as was NMDA-dependent behavior. We show that reconstitution of NMDA-gated current in Xenopus oocytes, or C. elegans muscle cells, depends on NRAP-1 and that recombinant NRAP-1 can convert silent NMDARs to functional channels. Our data indicate that NRAP-1, secreted from presynaptic neurons, localizes to glutamatergic synapses where it associates with postsynaptic NMDARs to modify receptor gating. Thus, our studies reveal a novel mechanism for synaptic regulation via pre-synaptic control of NMDAR-mediated synaptic transmission. Lei et al, have discovered NRAP-1, the first identified NMDAR auxiliary protein. NRAP-1, secreted from presynaptic neurons, modulates the properties of postsynaptic NMDA receptors. Trans-synaptic modulation of receptor function by NRAP-1 reveals a novel mechanism used to regulate synaptic strength.
登录
查看更多内容
影响因子：
2
作者：
McDonald JH;Dunn KW
通讯作者：
Dunn KW
影响因子：
34.7
作者：
Copits, Bryan A.;Swanson, Geoffrey T.
通讯作者：
Swanson, Geoffrey T.
影响因子：
56.9
作者：
Fremeau, RT;Kam, K;Edwards, RH
通讯作者：
Edwards, RH
影响因子：
16.2
作者：
Brockie PJ;Jensen M;Mellem JE;Jensen E;Yamasaki T;Wang R;Maxfield D;Thacker C;Hoerndli F;Dunn PJ;Tomita S;Madsen DM;Maricq AV
通讯作者：
Maricq AV
影响因子：
5.3
作者：
Lavezzari, G;McCallum, J;Roche, KW
通讯作者：
Roche, KW