Microglia during development and aging.
Microglia during development and aging.
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DOI：
10.1016/j.pharmthera.2013.04.013
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发表时间：
2013-09
影响因子：
13.5
通讯作者：
Harry, G. Jean
中科院分区：
文献类型：
--
作者：
Harry, G. Jean
小胶质细胞是影响脑发育、维持神经环境、对损伤的反应和修复的关键神经系统特异性细胞。它们有助于神经元的增殖和分化、垂死神经元的修剪、突触重塑以及碎片和异常蛋白的清除。大脑的定植发生在妊娠期，出生后随着程序性神经元死亡、突触修剪和轴突变性的刺激而扩大。小胶质细胞表型的变化与细胞过程有关，包括特定的神经递质、模式识别或免疫相关受体激活。在激活时，小胶质细胞具有释放许多物质的能力，例如，细胞因子、趋化因子、一氧化氮和活性氧物质，它们可能对周围细胞有害或有益。随着年龄的增长，小胶质细胞改变其形态，并可能显示出与迁移、清除相关的正常功能的能力减弱，以及从促炎状态转变为抗炎状态以调节损伤和修复的能力。小胶质细胞的这种变化可能导致易感性增加和神经退行性变作为年龄的函数。在目前的审查中，提供的信息殖民化的大脑由小胶质细胞，各种模式识别受体的表达，以调节迁移和吞噬作用，并在正常老化中发生的相关功能的转变。
Microglia are critical nervous system-specific cells influencing brain development, maintenance of the neural environment, response to injury, and repair. They contribute to neuronal proliferation and differentiation, pruning of dying neurons, synaptic remodeling and clearance of debris and aberrant proteins. Colonization of the brain occurs during gestation with an expansion following birth with localization stimulated by programmed neuronal death, synaptic pruning, andaxonal degeneration. Changes inmicroglia phenotype relate to cellular processes including specific neurotransmitter, pattern recognition, or immune-related receptor activation. Upon activation, microglia cells have the capacity to release a number of substances, e.g., cytokines, chemokines, nitric oxide, and reactive oxygen species, which could be detrimental or beneficial to the surrounding cells. With aging, microglia shift their morphology and may display diminished capacity for normal functions related to migration, clearance, and the ability to shift from a pro-inflammatory to an anti-inflammatory state to regulate injury and repair. This shift in microgliapotentially contributes to increased susceptibility and neurodegeneration as a function of age. In the current review, information is provided on the colonization of the brain by microglia, the expression of various pattern recognition receptors to regulate migration and phagocytosis, and the shift in related functions that occur in normal aging.
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影响因子：
4.2
作者：
Bachstetter, Adam D.;Morganti, Josh M.;Jernberg, Jennifer;Schlunk, Andrea;Mitchell, Staten H.;Brewster, Kaelin W.;Hudson, Charles E.;Cole, Michael J.;Harrison, Jeffrey K.;Bickford, Paula C.;Gemma, Carmelina
通讯作者：
Gemma, Carmelina
鉴定小鼠和男性的抗性和循环皮肤树突状细胞种群。
影响因子：
15.3
作者：
Bogunovic, Milena;Ginhoux, Florent;Wagers, Amy;Loubeau, Martine;Isola, Luis M.;Lubrano, Lauren;Najfeld, Vesna;Phelps, Robert G.;Grosskreutz, Celia;Scigliano, Eilleen;Frenette, Paul S.;Merad, Miriam
通讯作者：
Merad, Miriam
影响因子：
56.9
作者：
Beattie, EC;Stellwagen, D;Malenka, RC
通讯作者：
Malenka, RC
影响因子：
25
作者：
Ajami, Bahareh;Bennett, Jami L.;Rossi, Fabio M. V.
通讯作者：
Rossi, Fabio M. V.
影响因子：
4.7
作者：
Bernardino, Liliana;Balosso, Silvia;Vezzani, Annamaria
通讯作者：
Vezzani, Annamaria