Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men.
Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men.
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鉴定小鼠和男性的抗性和循环皮肤树突状细胞种群。
DOI：
10.1084/jem.20060667
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发表时间：
2006-11-27
影响因子：
15.3
通讯作者：
Merad, Miriam
中科院分区：
文献类型：
--
作者：
Bogunovic, Milena;Ginhoux, Florent;Wagers, Amy;Loubeau, Martine;Isola, Luis M.;Lubrano, Lauren;Najfeld, Vesna;Phelps, Robert G.;Grosskreutz, Celia;Scigliano, Eilleen;Frenette, Paul S.;Merad, Miriam
在这项研究中，我们探讨了小鼠和人的真皮树突状细胞（DC）稳态和造血细胞移植后的稳态。我们发现真皮DC在小鼠和人静止真皮中原位增殖。在具有分离器官但共享血液循环的联体小鼠中，大多数真皮DC在>6个月内未能被循环前体替代。在注射供体同源骨髓（BM）细胞的致死性照射小鼠中，受体DC的一个子集保留在真皮中，并在整个生命过程中局部增殖。与这些发现相一致的是，在异基因造血细胞移植后，尽管完全供体BM嵌合，但大部分受体真皮DC仍保留在患者的皮肤中。总的来说，我们的研究结果反对传统的观点，即DC是由循环前体维持的非分裂终末分化细胞，并支持新的范式，即组织DC具有局部增殖特性，控制其稳态。鉴于残留宿主组织DC在移植免疫反应中的作用，这些结果表明，真皮DC稳态可能有助于临床移植中皮肤移植物抗宿主病的发展。
In this study, we explored dermal dendritic cell (DC) homeostasis in mice and humans both in the steady state and after hematopoietic cell transplantation. We discovered that dermal DCs proliferate in situ in mice and human quiescent dermis. In parabiotic mice with separate organs but shared blood circulation, the majority of dermal DCs failed to be replaced by circulating precursors for >6 mo. In lethally irradiated mice injected with donor congenic bone marrow (BM) cells, a subset of recipient DCs remained in the dermis and proliferated locally throughout life. Consistent with these findings, a large proportion of recipient dermal DCs remained in patients' skin after allogeneic hematopoietic cell transplantation, despite complete donor BM chimerism. Collectively, our results oppose the traditional view that DCs are nondividing terminally differentiated cells maintained by circulating precursors and support the new paradigm that tissue DCs have local proliferative properties that control their homeostasis in the steady state. Given the role of residual host tissue DCs in transplant immune reactions, these results suggest that dermal DC homeostasis may contribute to the development of cutaneous graft-versus-host disease in clinical transplantation.
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影响因子：
32.4
作者：
Kabashima, K;Banks, TA;Cyster, JG
通讯作者：
Cyster, JG
影响因子：
10.3
作者：
CERIO, R;GRIFFITHS, CEM;HEADINGTON, JT
通讯作者：
HEADINGTON, JT
影响因子：
32.4
作者：
Cook, DN;Prosser, DM;Lira, SA
通讯作者：
Lira, SA
影响因子：
6.5
作者：
Dupasquier, M;Stoitzner, P;Leenen, PJM
通讯作者：
Leenen, PJM
影响因子：
4.4
作者：
Ebner, S;Ehammer, Z;Romani, N
通讯作者：
Romani, N