Healthy aging delays scalp EEG sensitivity to noise in a face discrimination task.
Healthy aging delays scalp EEG sensitivity to noise in a face discrimination task.
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DOI：
10.3389/fpsyg.2010.00019
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发表时间：
2010
影响因子：
3.8
通讯作者：
Sekuler AB
中科院分区：
文献类型：
--
作者：
Rousselet GA;Gaspar CM;Pernet CR;Husk JS;Bennett PJ;Sekuler AB
我们使用了一个单一的试验ERP的方法来量化与年龄相关的变化的时间过程中的噪音敏感性。共有62名年龄在19岁至98岁之间的健康成年人在两张面孔之间进行了非快速辨别任务。刺激信息的控制参数操纵这些面孔的相位谱。行为75%正确阈值随年龄增长而增加。这一结果可以用老年人大脑中较低的信噪比来解释。将每个受试者的ERP输入到单次试验一般线性回归模型中，以确定与图像结构变化相关的神经活动统计学变化。在多个刺激后时间点计算模型的拟合（以R2为索引）。R2函数的时间过程显示老年观察者的噪音敏感性显着延迟。这种年龄效应是可靠的，在24名受试者的重测证明，并开始刺激后约120毫秒。我们的分析还表明，在47 ± 4岁左右，大脑活动模式从年轻到老年发生了质的变化。
We used a single-trial ERP approach to quantify age-related changes in the time-course of noise sensitivity. A total of 62 healthy adults, aged between 19 and 98, performed a non-speeded discrimination task between two faces. Stimulus information was controlled by parametrically manipulating the phase spectrum of these faces. Behavioral 75% correct thresholds increased with age. This result may be explained by lower signal-to-noise ratios in older brains. ERP from each subject were entered into a single-trial general linear regression model to identify variations in neural activity statistically associated with changes in image structure. The fit of the model, indexed by R2, was computed at multiple post-stimulus time points. The time-course of the R2 function showed significantly delayed noise sensitivity in older observers. This age effect is reliable, as demonstrated by test–retest in 24 subjects, and started about 120 ms after stimulus onset. Our analyses suggest also a qualitative change from a young to an older pattern of brain activity at around 47 ± 4 years old.
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DOI：
10.1016/0168-5597(87)90023-2
发表时间：
1987-05-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
CELESIA, GG;KAUFMAN, D;CONE, S
通讯作者：
CONE, S
影响因子：
--
作者：
Bullier, J
通讯作者：
Bullier, J
影响因子：
1.8
作者：
Gold, J;Bennett, PJ;Sekuler, AB
通讯作者：
Sekuler, AB
影响因子：
1.8
作者：
Husk, Jesse S.;Bennett, Patrick J.;Sekuler, Allison B.
通讯作者：
Sekuler, Allison B.
影响因子：
56.9
作者：
Leventhal, AG;Wang, YC;Ma, YY
通讯作者：
Ma, YY