Y-chromosome evidence for common ancestry of three Chinese populations with a high risk of esophageal cancer.
Y-chromosome evidence for common ancestry of three Chinese populations with a high risk of esophageal cancer.
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三个中国食管癌高危人群的共同祖先的 Y 染色体证据。
DOI：
10.1371/journal.pone.0011118
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发表时间：
2010-06-15
期刊：
影响因子：
3.7
通讯作者：
Guo Y
中科院分区：
文献类型：
--
作者：
Huang H;Su M;Li X;Li H;Tian D;Gao Y;Guo Y
中国河南太行山、福建闽南、潮汕地区食管癌发病率较高。历史记载描述了从中国中北部（河南和山西汉族）通过沿海的福建省向潮汕平原迁移的人口浪潮。虽然这些地区在地理上是遥远的，我们假设，在这三个地区的EC高风险人群可能有共同的祖先。因此，我们使用16个东亚特有的Y染色体双等位基因标记（单核苷酸多态性; Y-SNPs）和6个Y染色体短串联重复序列（Y-STR）位点来推断EC高危潮汕群体（CSP）的起源以及CSP与EC高危河南太行山群体（HTMP）和福建群体（FJP）之间的遗传关系。在这三个群体中的优势单倍型群是O3*，O3 e * 和O3 e1，这些基因型的频率在群体之间没有显着差异。频率分布和主成分分析表明，CSP是密切相关的HTMP和FJP，即使前者在地理上更接近其他人群（广府和客家宗族）。在主成分图中，FJP介于CSP和HTMP之间。CSP，FJP和HTMP与中国汉族的关系比少数民族更密切，除了满族，并且是汉藏人的后裔，而不是百越人。相关分析、系统聚类分析和系统发育树分析均支持CSP、FJP和HTMP之间的亲缘关系。单倍群O3（包括O3*、O3 e * 和O3 e1）的网络显示HTMP具有最高的STR单倍型多样性，提示HTMP可能是CSP和FJP的祖先群体。这些发现支持了共同祖先在了解更多关于高危人群EC病因学遗传易感性方面的潜在重要作用，并对确定这种疾病的分子基础具有影响。
High rates of esophageal cancer (EC) are found in people of the Henan Taihang Mountain, Fujian Minnan, and Chaoshan regions of China. Historical records describe great waves of populations migrating from north-central China (the Henan and Shanxi Hans) through coastal Fujian Province to the Chaoshan plain. Although these regions are geographically distant, we hypothesized that EC high-risk populations in these three areas could share a common ancestry. Accordingly, we used 16 East Asian-specific Y-chromosome biallelic markers (single nucleotide polymorphisms; Y-SNPs) and six Y-chromosome short tandem repeat (Y-STR) loci to infer the origin of the EC high-risk Chaoshan population (CSP) and the genetic relationship between the CSP and the EC high-risk Henan Taihang Mountain population (HTMP) and Fujian population (FJP). The predominant haplogroups in these three populations are O3*, O3e*, and O3e1, with no significant difference between the populations in the frequency of these genotypes. Frequency distribution and principal component analysis revealed that the CSP is closely related to the HTMP and FJP, even though the former is geographically nearer to other populations (Guangfu and Hakka clans). The FJP is between the CSP and HTMP in the principal component plot. The CSP, FJP and HTMP are more closely related to Chinese Hans than to minorities, except Manchu Chinese, and are descendants of Sino-Tibetans, not Baiyues. Correlation analysis, hierarchical clustering analysis, and phylogenetic analysis (neighbor-joining tree) all support close genetic relatedness among the CSP, FJP and HTMP. The network for haplogroup O3 (including O3*, O3e* and O3e1) showed that the HTMP have highest STR haplotype diversity, suggesting that the HTMP may be a progenitor population for the CSP and FJP. These findings support the potentially important role of shared ancestry in understanding more about the genetic susceptibility in EC etiology in high-risk populations and have implications for determining the molecular basis of this disease.
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DOI：
10.1007/bf02879329
发表时间：
2001-06-01
期刊：
SCIENCE IN CHINA SERIES C-LIFE SCIENCES
影响因子：
--
作者：
Ke, YH;Su, B;Lu, DR
通讯作者：
Lu, DR
DOI：
10.1360/yc-006-1495
发表时间：
2006-12-01
期刊：
Yichuan
影响因子：
--
作者：
He Yan;Shan Ke-Ren;Ren Xi-Lin
通讯作者：
Ren Xi-Lin
影响因子：
9.8
作者：
Su, B;Xiao, JH;Jin, L
通讯作者：
Jin, L
影响因子：
7.7
作者：
Chang-Claude, J;Becher, H;Wahrendorf, J
通讯作者：
Wahrendorf, J
DOI：
10.4028/www.scientific.net/kem.177-180.1
发表时间：
2000-01-01
期刊：
ADVANCES IN ENGINEERING PLASTICITY, PTS 1-2
影响因子：
--
作者：
Huang, ZP;Li, HL
通讯作者：
Li, HL