Modulation of signaling pathways in prostate cancer by green tea polyphenols.
Modulation of signaling pathways in prostate cancer by green tea polyphenols.
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DOI：
10.1016/j.bcp.2012.09.027
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发表时间：
2013-03-01
影响因子：
5.8
通讯作者：
Mukhtar, Hasan
中科院分区：
文献类型：
--
作者：
Khan, Naghma;Mukhtar, Hasan
前列腺癌 (PCa) 是美国男性中最常见的恶性肿瘤，PCa 的危险因素包括年龄、家族史、种族、激素状态、饮食和生活方式。为了成功开发癌症预防/治疗方法，食用能够抑制或延缓癌细胞生长和增殖而不显着影响正常细胞的膳食制剂可能是一种有效的策略。从绿茶中提取的多酚，称为绿茶多酚（GTP），近年来因其有益作用而受到极大关注，特别是它们在癌症化学预防和化疗中的重要作用。几项研究报告了 GTP 在体外和体内方法以及人体临床试验中的有益效果。在绿茶儿茶素中，表没食子儿茶素-3-没食子酸酯 (EGCG) 因其预防癌症的特性而被研究得最好。在这篇综述文章中，我们介绍了有关 GTP 和 EGCG 对 PCa 信号通路影响的现有科学文献。
Prostate cancer (PCa) is the most common malignancy found in American men and the risk factors for PCa include age, family history, ethnicity, hormonal status, diet and lifestyle. For the successful development of cancer-preventive/therapeutic approaches, consumption of dietary agents capable of inhibiting or delaying the growth and proliferation of cancer cells without significantly affecting normal cells could be an effective strategy. Polyphenols derived from green tea, termed as green tea polyphenols (GTP) have received great attention in recent years for their beneficial effects, in particular, their significant involvement in cancer chemoprevention and chemotherapy. Several studies have reported beneficial effects of GTP using in-vitro and in-vivo approaches and in human clinical trials. Among green tea catechins, epigallocatechin-3-gallate (EGCG) is best studied for its cancer preventive properties. In this review article, we present available scientific literature about the effects of GTP and EGCG on signaling pathways in PCa.
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DOI：
10.1080/01635580903285056
发表时间：
2009
期刊：
Nutrition and cancer
影响因子：
--
作者：
Khan N;Adhami VM;Mukhtar H
通讯作者：
Mukhtar H
影响因子：
11.5
作者：
Adhami, Vaqar Mustafa;Malik, Arshi;Mukhtar, Hasan
通讯作者：
Mukhtar, Hasan
影响因子：
5
作者：
Kurahashi, Norie;Sasazuki, Shizuka;Tsugane, Shoichiro
通讯作者：
Tsugane, Shoichiro
影响因子：
3.9
作者：
Gupta, S;Hussain, T;Mukhtar, H
通讯作者：
Mukhtar, H
影响因子：
5.1
作者：
Albrecht, Daniel S.;Clubbs, Elizabeth A.;Bomser, Joshua A.
通讯作者：
Bomser, Joshua A.