Factor XIII B subunit polymorphisms and the risk of coronary artery disease.
Factor XIII B subunit polymorphisms and the risk of coronary artery disease.
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DOI：
10.3390/ijms16011143
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发表时间：
2015-01-06
影响因子：
5.6
通讯作者：
Muszbek L
中科院分区：
文献类型：
--
作者：
Mezei ZA;Bereczky Z;Katona É;Gindele R;Balogh E;Fiatal S;Balogh L;Czuriga I;Ádány R;Édes I;Muszbek L
本病例对照研究的目的是探讨凝血因子XIII（FXIII）B亚单位（FXIII-B）多态性对冠心病风险和FXIII水平的影响。在这项研究中，687名患者入院进行冠状动脉造影，以调查可疑的冠状动脉疾病和994人代表匈牙利人口入组。根据是否存在显著的冠状动脉粥样硬化（CAS）和心肌梗死（MI）病史对患者进行分类。对F13 B基因进行p.His95Arg和内含子K nt 29756 C>G多态性的基因分型;后者导致10个C-末端氨基酸被25个新氨基酸取代。p.His95Arg多态性对CAS或MI的风险没有影响。FXIII-B内含子K nt 29756 G等位基因在纤维蛋白原水平在上三分位数的患者中提供了针对CAS和MI的显著保护。然而，这种效应仅在FXIII-A Leu 34等位基因的存在下占上风，并且揭示了两种多态性之间的协同作用。内含子Knt 29756 G等位基因携带者具有显著较低的FXIII水平，并且在较低的三分位数中的FXIII水平提供针对MI的显著保护。这表明，组合的多态性的保护作用与降低FXIII水平。
The aim of the case-control study was to explore the effect of coagulation factor XIII (FXIII) B subunit (FXIII-B) polymorphisms on the risk of coronary artery disease, and on FXIII levels. In the study, 687 patients admitted for coronary angiography to investigate suspected coronary artery disease and 994 individuals representing the Hungarian population were enrolled. The patients were classified according to the presence of significant coronary atherosclerosis (CAS) and history of myocardial infarction (MI). The F13B gene was genotyped for p.His95Arg and for intron K nt29756 C>G polymorphisms; the latter results in the replacement of 10 C-terminal amino acids by 25 novel amino acids. The p.His95Arg polymorphism did not influence the risk of CAS or MI. The FXIII-B intron K nt29756 G allele provided significant protection against CAS and MI in patients with a fibrinogen level in the upper tertile. However, this effect prevailed only in the presence of the FXIII-A Leu34 allele, and a synergism between the two polymorphisms was revealed. Carriers of the intron K nt29756 G allele had significantly lower FXIII levels, and FXIII levels in the lower tertile provided significant protection against MI. It is suggested that the protective effect of the combined polymorphisms is related to decreased FXIII levels.
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影响因子：
9.5
作者：
Fedele F;Mancone M;Chilian WM;Severino P;Canali E;Logan S;De Marchis ML;Volterrani M;Palmirotta R;Guadagni F
通讯作者：
Guadagni F
影响因子：
1.8
作者：
Cortina-Borja M;Smith AD;Combarros O;Lehmann DJ
通讯作者：
Lehmann DJ
影响因子：
2.9
作者：
LEIFHEIT, HJ;CLEVE, H
通讯作者：
CLEVE, H
影响因子：
20.3
作者：
Katona, Eva;Penzes, Krisztina;Muszbek, Laszlo
通讯作者：
Muszbek, Laszlo
影响因子：
12.8
作者：
RODEGHIERO, F;TOSETTO, A;CASTAMAN, G
通讯作者：
CASTAMAN, G