A genome-wide association study of depressive symptoms.
A genome-wide association study of depressive symptoms.
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DOI：
10.1016/j.biopsych.2012.09.033
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发表时间：
2013-04-01
影响因子：
10.6
通讯作者：
Murabito, Joanne
中科院分区：
文献类型：
--
作者：
Hek, Karin;Demirkan, Ayse;Lahti, Jari;Terracciano, Antonio;Teumer, Alexander;Cornelis, Marilyn C.;Amin, Najaf;Bakshis, Erin;Baumert, Jens;Ding, Jingzhong;Liu, Yongmei;Marciante, Kristin;Meirelles, Osorio;Nalls, Michael A.;Sun, Yan V.;Vogelzangs, Nicole;Yu, Lei;Bandinelli, Stefania;Benjamin, Emelia J.;Bennett, David A.;Boomsma, Dorret;Cannas, Alessandra;Coker, Laura H.;de Geus, Eco;De Jager, Philip L.;Diez-Roux, Ana V.;Purcell, Shaun;Hu, Frank B.;Rimm, Eric B.;Hunter, David J.;Jensen, Majken K.;Curhan, Gary;Rice, Kenneth;Penman, Alan D.;Rotter, Jerome I.;Sotoodehnia, Nona;Emeny, Rebecca;Eriksson, Johan G.;Evans, Denis A.;Ferrucci, Luigi;Fornage, Myriam;Gudnason, Vilmundur;Hofman, Albert;Illig, Thomas;Kardia, Sharon;Kelly-Hayes, Margaret;Koenen, Karestan;Kraft, Peter;Kuningas, Maris;Massaro, Joseph M.;Melzer, David;Mulas, Antonella;Mulder, Cornelis L.;Murray, Anna;Oostra, Ben A.;Palotie, Aarno;Penninx, Brenda;Petersmann, Astrid;Pilling, Luke C.;Psaty, Bruce;Rawal, Rajesh;Reiman, Eric M.;Schulz, Andrea;Shulman, Joshua M.;Singleton, Andrew B.;Smith, Albert V.;Sutin, Angelina R.;Uitterlinden, Andre G.;Voelzke, Henry;Widen, Elisabeth;Yaffe, Kristine;Zonderman, Alan B.;Cucca, Francesco;Harris, Tamara;Ladwig, Karl-Heinz;Llewellyn, David J.;Raikkonen, Katri;Tanaka, Toshiko;van Duijn, Cornelia M.;Grabe, Hans J.;Launer, Lenore J.;Lunetta, Kathryn L.;Mosley, Thomas H., Jr.;Newman, Anne B.;Tiemeier, Henning;Murabito, Joanne
关键词：
抑郁症是一种遗传特征，存在于不同严重程度和持续时间的连续体上。然而，寻找与抑郁症相关的遗传变异几乎没有成功。我们利用抑郁症的整个连续性来寻找抑郁症状的常见变体。在这项全基因组关联研究中，我们将17项基于人群的研究结果与流行病学研究中心抑郁量表评估抑郁症状相结合。在5项使用其他工具评估抑郁症状的研究中，重复了独立的最高命中率（p < 1 × 10−5）。此外，我们对所有22项发现和复制研究进行了综合荟萃分析。发现样本包括34，549个个体（平均年龄为66.5岁），没有位点达到全基因组显著性（最低p = 1.05 × 10−7）。七个独立的单核苷酸多态性被认为是复制。在重复组（n = 16，709）中，我们发现一个单核苷酸多态性与抑郁症状（rs161645，5q21，p = 9.19 × 10−3）有关联。在结合发现和复制研究（n = 51，258）的总体荟萃分析中，5q21区域达到了全基因组显著性（p = 4.78 × 10−8）。结果表明，只有包含超过50，000名受试者的大样本才有足够的能力检测抑郁症状的基因。
Depression is a heritable trait that exists on a continuum of varying severity and duration. Yet, the search for genetic variants associated with depression has had few successes. We exploit the entire continuum of depression to find common variants for depressive symptoms. In this genome-wide association study, we combined the results of 17 population-based studies assessing depressive symptoms with the Center for Epidemiological Studies Depression Scale. Replication of the independent top hits (p < 1 × 10−5) was performed in five studies assessing depressive symptoms with other instruments. In addition, we performed a combined meta-analysis of all 22 discovery and replication studies. The discovery sample comprised 34,549 individuals (mean age of 66.5) and no loci reached genome-wide significance (lowest p = 1.05 × 10−7). Seven independent single nucleotide polymorphisms were considered for replication. In the replication set (n = 16,709), we found suggestive association of one single nucleotide polymorphism with depressive symptoms (rs161645, 5q21, p = 9.19 × 10−3). This 5q21 region reached genome-wide significance (p = 4.78 × 10−8) in the overall meta-analysis combining discovery and replication studies (n = 51,258). The results suggest that only a large sample comprising more than 50,000 subjects may be sufficiently powered to detect genes for depressive symptoms.
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影响因子：
11.3
作者：
BRESLAU, N
通讯作者：
BRESLAU, N
影响因子：
5
作者：
HARLOW, SD;GOLDBERG, EL;COMSTOCK, GW
通讯作者：
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作者：
Bosker, F. J.;Hartman, C. A.;Nolen, W. A.
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影响因子：
158.5
作者：
Barker, DJP;Osmond, C;Eriksson, JG
通讯作者：
Eriksson, JG
DOI：
10.1111/j.1532-5415.2000.tb03873.x
发表时间：
2000-12-01
影响因子：
6.3
作者：
Ferrucci, L;Bandinelli, S;Guralnik, JM
通讯作者：
Guralnik, JM