Effectiveness of Microecological Preparations for Improving Renal Function and Metabolic Profiles in Patients With Chronic Kidney Disease.
Effectiveness of Microecological Preparations for Improving Renal Function and Metabolic Profiles in Patients With Chronic Kidney Disease.
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DOI：
10.3389/fnut.2022.850014
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发表时间：
2022
影响因子：
5
通讯作者：
Qin, Wei
中科院分区：
文献类型：
--
作者：
Tan, Jiaxing;Zhou, Huan;Deng, Jiaxin;Sun, Jiantong;Zhou, Xiaoyuan;Tang, Yi;Qin, Wei
确定微生态制剂，包括益生菌，益生元和合生元，是否对慢性肾脏疾病（CKD）患者有益一直存在争议。此外，确定哪种制剂具有最佳效果仍不清楚。在本研究中，我们对随机临床试验（RCT）进行了网络荟萃分析，以解决这些问题。检索MEDLINE、EMBASE、PubMed、Web of Science和科克伦对照试验中心注册中心。纳入了接受益生菌、益生元和/或合生元干预措施的CKD患者的合格RCT。结局指标包括肾功能、血脂、炎症因子和氧化应激因子的变化。最终纳入了28项随机对照试验，共1,373例患者。与安慰剂相比，益生菌在降低血清肌酐[平均差异（MD）-0.21，95%置信区间（CI）-0.34，-0.09]和甘油三酯（MD-9.98，95% CI-19.47，-0.49）方面表现出更大的效果，累积排名曲线下的表面积最大，而益生元和合生元没有表现出优势。益生菌还能够减少丙二醛（MDA）（MD −0.54，95% CI −0.96，−0.13）和增加谷胱甘肽（MD 72.86，95% CI 25.44，120.29）。益生元在降低高敏C反应蛋白（MD-2.06，95% CI-3.79，-0.32）和肿瘤坏死因子-α（MD-2.65，95% CI-3.91，-1.39）方面表现出更大的疗效。合生元在降低MDA（MD −0.66，95%CI −1.23，−0.09）和高敏C反应蛋白（MD −2.01，95%CI −3.87，−0.16）以及提高总抗氧化能力（MD 145.20，95%CI 9.32，281.08）方面表现出部分协同作用。结果表明，微生物补充剂改善了CKD患者的肾功能和脂质谱，并对氧化应激和炎症指标产生了有利影响。综合考虑，益生菌对CKD患者的作用最为全面和有益，可能是微生态制剂的最佳选择。https://www.crd.york.ac.uk/prospero/display_record.php? ID= CRD 42022295497，PROSPERO 2022，标识符：CRD 42022295497。
Determining whether microecological preparations, including probiotics, prebiotics, and synbiotics, are beneficial for patients with chronic kidney disease (CKD) has been debated. Moreover, determining which preparation has the best effect remains unclear. In this study, we performed a network meta-analysis of randomized clinical trials (RCTs) to address these questions. MEDLINE, EMBASE, PubMed, Web of Science, and the Cochrane Central Register of Controlled Trials were searched. Eligible RCTs with patients with CKD who received intervention measures involving probiotics, prebiotics, and/or synbiotics were included. The outcome indicators included changes in renal function, lipid profiles, inflammatory factors, and oxidative stress factors. Twenty-eight RCTs with 1,373 patients were ultimately included. Probiotics showed greater effect in lowering serum creatinine [mean difference (MD) −0.21, 95% confidence interval (CI) −0.34, −0.09] and triglycerides (MD −9.98, 95% CI −19.47, −0.49) than the placebo, with the largest surface area under the cumulative ranking curve, while prebiotics and synbiotics showed no advantages. Probiotics were also able to reduce malondialdehyde (MDA) (MD −0.54, 95% CI −0.96, −0.13) and increase glutathione (MD 72.86, 95% CI 25.44, 120.29). Prebiotics showed greater efficacy in decreasing high-sensitivity C-reactive protein (MD −2.06, 95% CI −3.79, −0.32) and tumor necrosis factor-α (MD −2.65, 95% CI −3.91, −1.39). Synbiotics showed a partially synergistic function in reducing MDA (MD −0.66, 95% CI −1.23, −0.09) and high-sensitivity C-reactive protein (MD −2.01, 95% CI −3.87, −0.16) and increasing total antioxidant capacity (MD 145.20, 95% CI 9.32, 281.08). The results indicated that microbial supplements improved renal function and lipid profiles and favorably affected measures of oxidative stress and inflammation in patients with CKD. After thorough consideration, probiotics provide the most comprehensive and beneficial effects for patients with CKD and might be used as the best choice for microecological preparations. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022295497, PROSPERO 2022, identifier: CRD42022295497.
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影响因子：
4.9
作者：
Arani, Navid Mazruei;Emam-Djomeh, Zahra;Asemi, Zatollah
通讯作者：
Asemi, Zatollah
影响因子：
39.2
作者：
Hutton, Brian;Salanti, Georgia;Moher, David
通讯作者：
Moher, David
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影响因子：
4.2
作者：
Cosola C;Rocchetti MT;di Bari I;Acquaviva PM;Maranzano V;Corciulo S;Di Ciaula A;Di Palo DM;La Forgia FM;Fontana S;De Angelis M;Portincasa P;Gesualdo L
通讯作者：
Gesualdo L
通过抑制组蛋白脱乙酰基酶，短链脂肪酸通过短链脂肪酸重定向。
影响因子：
7.3
作者：
Lin MY;de Zoete MR;van Putten JP;Strijbis K
通讯作者：
Strijbis K
影响因子：
5.9
作者：
de Andrade LS;Sardá FAH;Pereira NBF;Teixeira RR;Rodrigues SD;de Lima JD;Dalboni MA;Aoike DT;Nakao LS;Cuppari L
通讯作者：
Cuppari L