In vivo characterization of the aortic wall stress-strain relationship.
In vivo characterization of the aortic wall stress-strain relationship.
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DOI：
10.1016/j.ultras.2010.01.003
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发表时间：
2010-06
期刊：
影响因子：
4.2
通讯作者：
Konofagou, Elisa E.
中科院分区：
文献类型：
--
作者：
Danpinid, Asawinee;Luo, Jianwen;Vappou, Jonathan;Terdtoon, Pradit;Konofagou, Elisa E.
Arterial stiffness has been shown to be a good indicator of the arterial wall diseases. However, a single parameter is insufficient to describe the complex stress-strain relationship of a multi-component, non-linear tissue such as the aorta. We therefore propose a new approach to measure the stress-strain relationship locally in vivo and present a noninvasively, clinically relevant parameter describing the mechanical interaction between aortic wall constituents. The slope change of the circumferential stress-strain curve was hypothesized as a contribution of elastin and collagen, which was noninvasively defined in the term of strain using only radial aortic wall acceleration, i.e., transition strain . Two-spring parallel was employed as the phenomenological model and three Young's moduli were accordingly evaluated, i.e., corresponding to the: elastic lamellae (E1), elastin-collagen fibers (E2) and collagen fibers (E3). Our study performed on normal and Angiotensin II (AngII)-treated mouse abdominal aortas using aortic pressure from catheterization and local aortic wall diameters from a cross-correlation technique on the radio frequency (RF) ultrasound signal at 30 MHz and frame rate of 8 kHz. Using our technique, transition strain and three Young’s moduli in both normal and pathological aortas were mapped in 2D. In the results, the slope change of the circumferential stress-strain curve was first observed in vivo under physiologic conditions. The transition strain was identified at the lower strain level in the AngII-treated case, i.e., 0.029±0.006 of normal and 0.012±0.004 of AngII-treated aortas. E1, E2 and E3 were 69.7±18.6, 214.5±65.8 and 144.8±55.2 kPa for normal aortas, respectively, and 222.1±114.8, 775.0±586.4 and 552.9±519.1 kPa for AngII-treated aortas, respectively. This is because of the alteration of structures and content of the wall constituents, the degradation of elastic lamella and collagen formation due to AngII treatment. While such values illustrate the alteration of structure and content of the wall constituents related to AngII treatment, limitations regarding physical assumptions (isotropic linear elastic) should be kept in mind. The transition strain, however, was shown to be an aortic pressure waveform independent parameter that can be clinically relevant and noninvasively measured using ultrasound-based motion estimation techniques. In conclusion, our novel methodology can assess the stress-strain relationship of the aortic wall locally in vivo and quantify informative parameters which are related to vascular disease.
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影响因子：
2
作者：
Holzapfel, GA;Gasser, TC;Ogden, RW
通讯作者：
Ogden, RW
影响因子：
--
作者：
COX, RH
通讯作者：
COX, RH
影响因子：
2
作者：
Holzapfel, GA
通讯作者：
Holzapfel, GA
影响因子：
1.5
作者：
Hall, AJ;Busse, EFG;Burgess, JJ
通讯作者：
Burgess, JJ
DOI：
10.1161/01.atv.5.1.19
发表时间：
1985-01-01
期刊：
ARTERIOSCLEROSIS
影响因子：
--
作者：
CLARK, JM;GLAGOV, S
通讯作者：
GLAGOV, S