Pathology of TB/COVID-19 Co-Infection: The phantom menace.
Pathology of TB/COVID-19 Co-Infection: The phantom menace.
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DOI：
10.1016/j.tube.2020.102020
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Fiegenbaum M
中科院分区：
文献类型：
--
作者：
Mousquer GT;Peres A;Fiegenbaum M
结核病（TB）和2019年冠状病毒病（COVID-19）目前是传染病中导致死亡的两大主要原因。越来越多的研究试图阐明结核分枝杆菌与SARS-CoV-2之间的相互作用。一些首批病例报告指出，合并感染结核病/COVID-19的患者呼吸道症状恶化。然而，来自队列研究的数据显示了一些相互矛盾的结果。本研究拟对现有关于TB/COVID-19合并感染队列的文献进行系统综述，评估临床和流行病学数据，重点关注其对免疫系统的影响。从免疫学角度来看，结核病/COVID-19合并感染有可能汇聚成一场“完美风暴”。每一种病原体对免疫调节的失调往往会引起不平衡的炎症反应，从而促进两种疾病的进展和恶化。了解结核分枝杆菌和SARS-CoV-2之间相互作用的性质对于制定针对合并感染的治疗策略至关重要。
Tuberculosis (TB) and coronavirus disease 2019 (COVID-19) are currently the two main causes of death among infectious diseases. There is an increasing number of studies trying to elucidate the interactions between Mycobacterium tuberculosis and SARS-CoV-2. Some of the first case reports point to a worsening of respiratory symptoms in co-infected TB/COVID-19 individuals. However, data from the cohort studies has shown some conflicting results. This study proposes to conduct a systematic review on the current literature on TB/COVID-19 co-infection cohorts, evaluating clinical and epidemiological data, focusing on its implications to the immune system. From an immunological perspective, the TB/COVID-19 co-infection has the potential to converge in a "perfect storm". The disorders induced by each pathogen to the immunomodulation tend to induce an unbalanced inflammatory response, which can promote the progression and worsening of both diseases. Understanding the nature of the interactions between M. tuberculosis and SARS-CoV-2 will be crucial for the development of therapeutic strategies against co-infection.
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影响因子：
7.3
作者：
Heitmann, Lisa;Dar, Mahin Abad;Schreiber, Tanja;Erdmann, Hanna;Behrends, Jochen;Mckenzie, Andrew N. J.;Brombacher, Frank;Ehlers, Stefan;Hoelscher, Christoph
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通讯作者：
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作者：
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通讯作者：
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