Influence of host iron status on Plasmodium falciparum infection.
Influence of host iron status on Plasmodium falciparum infection.
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DOI：
10.3389/fphar.2014.00084
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发表时间：
2014
影响因子：
5.6
通讯作者：
Cerami C
中科院分区：
文献类型：
--
作者：
Clark MA;Goheen MM;Cerami C
缺铁影响世界人口的四分之一，并导致严重的发病率，包括对免疫功能和认知发育的有害影响。因此，世界卫生组织（世卫组织）建议在缺铁高发地区的儿童和成人中进行常规补铁。然而，大量的临床和流行病学证据已经积累，这清楚地表明，主机缺铁是保护免受恶性疟疾和主机铁补充剂可能会增加疟疾的风险。虽然有许多有效的抗疟治疗和预防措施，但疟疾仍然是一个重大的公共卫生问题，部分原因是疟疾发病机制仍然被寄生虫毒力因子、宿主易感性特征和调节疾病的免疫反应之间存在的复杂关系所掩盖。在这里，我们审查（一）的临床和流行病学数据，描述了宿主铁状态和疟疾感染之间的关系，（二）目前的理解，这些临床和流行病学观察的生物学基础。
Iron deficiency affects one quarter of the world's population and causes significant morbidity, including detrimental effects on immune function and cognitive development. Accordingly, the World Health Organization (WHO) recommends routine iron supplementation in children and adults in areas with a high prevalence of iron deficiency. However, a large body of clinical and epidemiological evidence has accumulated which clearly demonstrates that host iron deficiency is protective against falciparum malaria and that host iron supplementation may increase the risk of malaria. Although many effective antimalarial treatments and preventive measures are available, malaria remains a significant public health problem, in part because the mechanisms of malaria pathogenesis remain obscured by the complexity of the relationships that exist between parasite virulence factors, host susceptibility traits, and the immune responses that modulate disease. Here we review (i) the clinical and epidemiological data that describes the relationship between host iron status and malaria infection and (ii) the current understanding of the biological basis for these clinical and epidemiological observations.
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影响因子：
2.1
作者：
GABAY, T;GINSBURG, H
通讯作者：
GINSBURG, H
影响因子：
2.4
作者：
Cabantchik, ZI;Glickstein, H;Tsafack, A
通讯作者：
Tsafack, A
影响因子：
6.4
作者：
Chang, KH;Tam, M;Stevenson, MM
通讯作者：
Stevenson, MM
影响因子：
6.4
作者：
Chotivanich, K;Udomsangpetch, R;White, NJ
通讯作者：
White, NJ
DOI：
10.1111/j.1574-695x.1999.tb01401.x
发表时间：
1999-12-01
影响因子：
--
作者：
Cabantchik, ZI;Moody-Haupt, S;Gordeuk, VR
通讯作者：
Gordeuk, VR