miR-205 and miR-200c: Predictive Micro RNAs for Lymph Node Metastasis in Triple Negative Breast Cancer.
miR-205 and miR-200c: Predictive Micro RNAs for Lymph Node Metastasis in Triple Negative Breast Cancer.
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DOI：
10.4048/jbc.2014.17.2.143
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发表时间：
2014-06
影响因子：
2.4
通讯作者：
Demirel D
中科院分区：
文献类型：
--
作者：
Berber U;Yilmaz I;Narli G;Haholu A;Kucukodaci Z;Demirel D
We examined expression profiles of 16 micro RNAs (miRNAs) in triple negative breast cancers to identify their potential as biomarkers for lymph node metastasis. The expression profiles of miR-9, miR-21, miR-30a, miR-30d, miR-31, miR-34a, miR-34c, miR-100, miR-122, miR-125b, miR-146a, miR-146b, miR-155, miR-181a, miR-200c, and miR-205 were examined by using real-time quantitative reverse transcription polymerase chain reaction in tumor samples and corresponding benign breast tissues. Their associations with histopathological features and prognostic parameters were assessed. When compared with the expression in benign breast tissues, seven of the miRNAs (miR-31, miR-205, miR-34a, miR-146a, miR-125b, miR-34c, and miR-181a) were downregulated more than 1.5-fold in tumor tissues, whereas, only miR-21 was found to be upregulated more than 1.5-fold in tumor tissues. Although miR-200c levels were decreased only 1.12-fold in tumor tissues, the reduced expressions of miR-200c and miR-205 were significantly associated with lymph node metastasis (p=0.021 and p=0.016, respectively). Our results demonstrate that miR-205 and miR-200c expression levels may be useful in predicting lymph node metastasis in triple negative breast cancer patients.
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影响因子：
37.3
作者：
Augoff K;McCue B;Plow EF;Sossey-Alaoui K
通讯作者：
Sossey-Alaoui K
DOI：
10.1186/bcr2766
发表时间：
2010
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Roth C;Rack B;Müller V;Janni W;Pantel K;Schwarzenbach H
通讯作者：
Schwarzenbach H
影响因子：
21.3
作者：
Wellner, Ulrich;Schubert, Joerg;Brabletz, Thomas
通讯作者：
Brabletz, Thomas
microRNA在乳腺癌迁移，侵袭和转移中的作用。
影响因子：
5.6
作者：
Tang J;Ahmad A;Sarkar FH
通讯作者：
Sarkar FH
影响因子：
--
作者：
Savad, Shahram;Mehdipour, Parvin;Modarressi, Mohammad Hossein
通讯作者：
Modarressi, Mohammad Hossein