Alzheimer's disease neuroimaging initiative: a one-year follow up study using tensor-based morphometry correlating degenerative rates, biomarkers and cognition.
Alzheimer's disease neuroimaging initiative: a one-year follow up study using tensor-based morphometry correlating degenerative rates, biomarkers and cognition.
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DOI：
10.1016/j.neuroimage.2009.01.004
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发表时间：
2009-04-15
期刊：
影响因子：
5.7
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
中科院分区：
文献类型：
--
作者：
Leow AD;Yanovsky I;Parikshak N;Hua X;Lee S;Toga AW;Jack CR Jr;Bernstein MA;Britson PJ;Gunter JL;Ward CP;Borowski B;Shaw LM;Trojanowski JQ;Fleisher AS;Harvey D;Kornak J;Schuff N;Alexander GE;Weiner MW;Thompson PM;Alzheimer's Disease Neuroimaging Initiative
基于张量的形态测量可以通过非线性地将基线配准到同一受试者的后续MRI扫描来恢复随时间的三维纵向脑变化。在这里，我们比较了纵向脑结构变化的解剖分布，超过12个月，使用ADNI数据集的一个子集，包括20名阿尔茨海默病（AD）患者，40名健康老年人对照组和40名轻度认知障碍（MCI）患者。使用无偏配准技术创建每个单独的纵向变化图（雅可比图），并基于健康对照将其空间归一化为几何中心的平均图像。体素统计分析揭示了萎缩率的区域差异，这些差异与临床指标和生物标志物相关。与先前的研究一致，我们检测到广泛的脑萎缩的AD，和更有限的萎缩模式MCI。在MCI中，颞叶萎缩率与简易精神状态检查（MMSE）评分、临床痴呆评分（CDR）和逻辑/语言学习记忆评分的变化相关。在AD中，颞叶萎缩率与几种生物标志物指数相关，包括较高的CSF p-tau蛋白水平和较高的CSF tau/β淀粉样蛋白1-42（A β 42）比值。转换为AD的MCI受试者的颞叶萎缩明显快于非转换者。因此，可以使用非线性图像配准分析连续MRI扫描，以将正在进行的神经变性与各种病理生物标志物、认知变化以及从MCI到AD的转换相关联，以三维细节跟踪疾病进展。
Tensor-based morphometry can recover three-dimensional longitudinal brain changes over time by nonlinearly registering baseline to follow-up MRI scans of the same subject. Here, we compared the anatomical distribution of longitudinal brain structural changes, over 12 months, using a subset of the ADNI dataset consisting of 20 patients with Alzheimer’s disease (AD), 40 healthy elderly controls, and 40 individuals with mild cognitive impairment (MCI). Each individual longitudinal change map (Jacobian map) was created using an unbiased registration technique, and spatially normalized to a geometrically-centered average image based on healthy controls. Voxelwise statistical analyses revealed regional differences in atrophy rates, and these differences were correlated with clinical measures and biomarkers. Consistent with prior studies, we detected widespread cerebral atrophy in AD, and a more restricted atrophic pattern in MCI. In MCI, temporal lobe atrophy rates were correlated with changes in mini-mental state exam (MMSE) scores, clinical dementia rating (CDR), and logical/verbal learning memory scores. In AD, temporal atrophy rates were correlated with several biomarker indices, including a higher CSF level of p-tau protein, and a greater CSF tau/beta amyloid 1-42 (ABeta42) ratio. Temporal lobe atrophy was significantly faster in MCI subjects who converted to AD than in non-converters. Serial MRI scans can therefore be analyzed with nonlinear image registration to relate ongoing neurodegeneration to a variety of pathological biomarkers, cognitive changes, and conversion from MCI to AD, tracking disease progression in 3-dimensional detail.
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影响因子：
1.3
作者：
COLLINS, DL;NEELIN, P;EVANS, AC
通讯作者：
EVANS, AC
影响因子：
5.7
作者：
Boyes, Richard G.;Rueckert, Daniel;Fox, Nicholas C.
通讯作者：
Fox, Nicholas C.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
5.7
作者：
Baron, JC;Chételat, G;Eustache, F
通讯作者：
Eustache, F
影响因子：
5.7
作者：
Chung, MK;Worsley, KJ;Evanst, AC
通讯作者：
Evanst, AC