Apolipoprotein A5: Extracellular and Intracellular Roles in Triglyceride Metabolism.
Apolipoprotein A5: Extracellular and Intracellular Roles in Triglyceride Metabolism.
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DOI：
10.2174/1389450116666150531161138
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发表时间：
2015
影响因子：
3.2
通讯作者：
Ryan RO
中科院分区：
文献类型：
--
作者：
Forte TM;Ryan RO
本文综述了载脂蛋白（apo）A5的两个主要功能：（1）维持正常血浆循环甘油三酯（TG）水平的作用和（2）作为肝脂滴组分的作用。ApoA5仅在肝脏中合成，循环浓度极低。在血浆中，apoA5与富含TG的脂蛋白结合并增强TG水解和残余脂蛋白清除。ApoA5功能丧失单核苷酸多态性与脂解减少、残留清除不良以及伴随的高甘油三酯血症相关。虽然在理解与分泌型apoA5相关的病理生理学方面已经有了实质性的突破，但对细胞内apoA5的功能性的了解仍然很少。然而，最近的研究表明，细胞内apoA5的过度表达与肝细胞中富含TG的脂滴的积累呈正相关。人们认为apoA5可能在非酒精性脂肪肝（NAFLD）中起因果作用，因此可以作为开发NAFLD治疗方法的靶点。
This review addresses two major functions of apolipoprotein (apo) A5 including (1) its role in maintaining normal plasma levels of circulating triglyceride (TG) and (2) its role as a component of hepatic lipid droplets. ApoA5 is synthesized solely in the liver and circulating concentrations are extremely low. In the plasma, apoA5 associates with TG-rich lipoproteins and enhances TG hydrolysis and remnant lipoprotein clearance. ApoA5 loss-of-function single nucleotide polymorphisms are associated with reduced lipolysis, poor remnant clearance and concomitantly, hypertriglyceridemia. Although there have been substantial breakthroughs in understanding pathophysiology associated with secreted apoA5, there is a paucity of knowledge on the functionality of intracellular apoA5. However, recent studies indicate that overexpression of intracellular apoA5 is positively associated with accumulation of TG-rich lipid droplets in hepatocytes. It is thought that apoA5 may have a causal role in non-alcoholic fatty liver disease (NAFLD) and thus, may serve as a target for developing therapeutics for NAFLD.
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影响因子：
29.4
作者：
Fabbrini, Elisa;Mohammed, B. Selma;Klein, Samuel
通讯作者：
Klein, Samuel
在人和大鼠非酒精脂肪肝肝中载脂蛋白A5表达增加。
影响因子：
4.5
作者：
Feng Q;Baker SS;Liu W;Arbizu RA;Aljomah G;Khatib M;Nugent CA;Baker RD;Forte TM;Hu Y;Zhu L
通讯作者：
Zhu L
影响因子：
6.5
作者：
Camporez JPG;Kanda S;Petersen MC;Jornayvaz FR;Samuel VT;Bhanot S;Petersen KF;Jurczak MJ;Shulman GI
通讯作者：
Shulman GI
影响因子：
2.3
作者：
Milic, Sandra;Stimac, Davor
通讯作者：
Stimac, Davor
影响因子：
4.8
作者：
Merkel, M;Loeffler, B;Heeren, J
通讯作者：
Heeren, J