Accelerating control of pertussis in England and Wales.
Accelerating control of pertussis in England and Wales.
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DOI：
10.3201/eid1801.110784
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发表时间：
2012-01
影响因子：
11.8
通讯作者：
Miller E
中科院分区：
文献类型：
--
作者：
Campbell H;Amirthalingam G;Andrews N;Fry NK;George RC;Harrison TG;Miller E
婴儿百日咳发病率可以通过早期完成初级疫苗接种计划来降低。1990年在英格兰和威尔士推出的婴儿百日咳疫苗接种加速计划的结果进行了检查。较早安排和持续的高疫苗覆盖率导致报告的婴儿百日咳病例减少，加强了世界卫生组织按时完成婴儿疫苗接种计划的努力。通过使用筛查方法确定，在6个月以下的婴儿中，第一剂疫苗的有效率为61.7%，并且有效性随着后续剂量的增加而增加。在10-16岁的儿童中，三剂良好的全细胞百日咳疫苗的有效率为83.7%;学龄前加强接种进一步降低了10岁以下儿童的百日咳发病率。与其他工业化国家一样，1998-2009年期间的监测数据显示，英格兰和威尔士的百日咳主要存在于幼儿中（即，<3个月）、青少年和成人。未来的疫苗计划变化可能是有益的，但需要更多的细节来告知这些决定。
Pertussis incidence among infants can be reduced by early completion of the primary vaccination schedule. Results of an accelerated pertussis vaccination schedule for infants introduced in 1990 in England and Wales were examined. Earlier scheduling and sustained high vaccine coverage resulted in fewer reported cases of pertussis among infants, reinforcing the World Health Organization drive for on-time completion of the infant vaccination schedule. As determined by using the screening method, the first dose of vaccine was 61.7% effective in infants <6 months of age, and effectiveness increased with subsequent doses. Three doses of a good whole-cell pertussis vaccine were 83.7% effective in children 10–16 years of age; a preschool booster vaccination further reduced pertussis incidence in children <10 years of age. As in other industrialized countries, surveillance data during 1998–2009 showed that pertussis in England and Wales mainly persists in young infants (i.e., <3 months of age), teenagers, and adults. Future vaccine program changes may be beneficial, but additional detail is required to inform such decisions.
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影响因子：
5.2
作者：
Crowcroft, NS;Andrews, N;Miller, E
通讯作者：
Miller, E
影响因子：
5.2
作者：
PALMER, SR
通讯作者：
PALMER, SR
影响因子：
8
作者：
Belloni, C;De Silvestri, A;Chirico, G
通讯作者：
Chirico, G
影响因子：
1.7
作者：
Somerville, Rebecca L.;Grant, Cameron C.;Thomas, Mark G.
通讯作者：
Thomas, Mark G.
影响因子：
5.2
作者：
Crowcroft, NS;Booy, R;Miller, E
通讯作者：
Miller, E