ZDHHC16 modulates FGF/ERK dependent proliferation of neural stem/progenitor cells in the zebrafish telencephalon
ZDHHC16 modulates FGF/ERK dependent proliferation of neural stem/progenitor cells in the zebrafish telencephalon
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ZDHHC16 调节斑马鱼端脑神经干细胞/祖细胞的 FGF/ERK 依赖性增殖
DOI：
10.1002/dneu.22372
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发表时间：
2016-09
影响因子：
3
通讯作者：
Hao Aijun
中科院分区：
文献类型：
--
作者：
Shi Wei;Chen Xueran;Wang Fen;Gao Ming;Yang Yang;Du Zhaoxia;Wang Chen;Yao Yao;He Kun;Hao Aijun
在脊椎动物中，神经干细胞/祖细胞（NSPCs）的维持对神经系统的发育和稳态至关重要。然而，NSPCs维持的分子机制尚未完全阐明。在这里，我们证明了斑马鱼在发育中的前脑，尤其是端脑中表达了一种与翻译后的蛋白棕榈酰化相关的DHHC编码蛋白ZDHHC16。功能丧失和功能获得研究表明，ZDHHC16在斑马鱼端脑发育过程中，通过依赖于其棕榈酰转移酶活性的机制，在NSPCs增殖的调节中发挥了关键作用。进一步分析表明，抑制ZDHHC16可导致端脑NSPCs增殖和维持过程中FGF/ERK信号通路失活。综上所述，我们的研究结果表明，ZDHHC16活性对于NSPCs的早期增殖至关重要，它可以激活FGF/ERK网络，从而启动增殖调节基因表达程序。©2016 Wiley期刊公司中国生物医学工程学报，2016,31 (6):1014-1028
In vertebrates, neural stem/progenitor cells (NSPCs) maintenance is critical for nervous system development and homeostasis. However, the molecular mechanisms underlying the maintenance of NSPCs have not been fully elucidated. Here, we demonstrated that zebrafish ZDHHC16, a DHHC encoding protein, which was related to protein palmitoylation after translation, was expressed in the developing forebrain, and especially in the telencephalon. Loss‐ and gain‐of‐function studies showed that ZDHHC16 played a crucial role in the regualtion of NSPCs proliferation during zebrafish telencephalic development, via a mechanism dependent on its palmitoyltransferase activity. Further analyses showed that the inhibition of ZDHHC16 led to inactivation of the FGF/ERK signaling pathway during telencephalic NSPCs proliferation and maintenance. Taken together, our results suggest that ZDHHC16 activity is essential for early NSPCs proliferation where it acts to activate the FGF/ERK network, allowing for the initiation of proliferation –regulated gene expression programs. © 2016 Wiley Periodicals, Inc. Develop Neurobiol 76: 1014–1028, 2016
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影响因子：
5.3
作者：
Del Puerto A;Wandosell F;Garrido JJ
通讯作者：
Garrido JJ
影响因子：
5.3
作者：
Laura Sánchez-Mir;A. Franco;R. Martín-García;Marisa Madrid;J. Vicente-Soler;T. Soto;M. Gacto;P. Pérez;J. Cansado
通讯作者：
Laura Sánchez-Mir;A. Franco;R. Martín-García;Marisa Madrid;J. Vicente-Soler;T. Soto;M. Gacto;P. Pérez;J. Cansado
DOI：
10.1523/jneurosci.2171-08.2008
发表时间：
2008-09-03
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Ponimaskin E;Dityateva G;Ruonala MO;Fukata M;Fukata Y;Kobe F;Wouters FS;Delling M;Bredt DS;Schachner M;Dityatev A
通讯作者：
Dityatev A
DOI：
10.1007/978-94-007-6621-1_8
发表时间：
2013-01-01
期刊：
TRANSCRIPTIONAL AND TRANSLATIONAL REGULATION OF STEM CELLS
影响因子：
--
作者：
Christie, Kimberly J.;Emery, Ben;Turnley, Ann M.
通讯作者：
Turnley, Ann M.
影响因子：
4.8
作者：
Li, Yi;Martin, Brent R.;Hofmann, Sandra L.
通讯作者：
Hofmann, Sandra L.