A magnetic hydrogel for the efficient retrieval of kidney stone fragments during ureteroscopy.
A magnetic hydrogel for the efficient retrieval of kidney stone fragments during ureteroscopy.
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DOI：
10.1038/s41467-023-38936-1
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发表时间：
2023-06-22
影响因子：
16.6
通讯作者：
Liao, Joseph C.
中科院分区：
文献类型：
--
作者：
Ge, T. Jessie;Roquero, Daniel Massana;Holton, Grace H.;Mach, Kathleen E.;Prado, Kris;Lau, Hubert;Jensen, Kristin;Chang, Timothy C.;Conti, Simon;Sheth, Kunj;Wang, Shan X.;Liao, Joseph C.
只有60%-75%的传统肾结石手术达到完全无结石状态。高达30%的残留碎片和2 mm大小的患者经历了随后的结石相关并发症。在这里，我们演示了一种石头回收技术，其中碎片可以用磁性水凝胶磁化，这样就可以用简单的磁性工具很容易地回收它们。磁性水凝胶有助于在体外强有力地捕获临床相关大小和成分的结石碎片。该水凝胶成分在细胞培养中无细胞毒性，对体外人尿路上皮和在体小鼠膀胱仅有表面作用。此外，该水凝胶对常见泌尿病原体的抗菌活性与普通抗生素不相上下。通过实现肾结石碎片的有效取回，我们的方法可以提高结石排净率和患者预后。手术取石的成功受制于有效回收结石碎片的能力，导致结石清除不完全和随后的并发症。在这里，作者展示了一种磁性水凝胶的有效性和生物相容性，这种水凝胶在体外选择性地覆盖人肾结石碎片，允许使用磁丝完全提取它们。
Only 60-75% of conventional kidney stone surgeries achieve complete stone-free status. Up to 30% of patients with residual fragments <2 mm in size experience subsequent stone-related complications. Here we demonstrate a stone retrieval technology in which fragments are rendered magnetizable with a magnetic hydrogel so that they can be easily retrieved with a simple magnetic tool. The magnetic hydrogel facilitates robust in vitro capture of stone fragments of clinically relevant sizes and compositions. The hydrogel components exhibit no cytotoxicity in cell culture and only superficial effects on ex vivo human urothelium and in vivo mouse bladders. Furthermore, the hydrogel demonstrates antimicrobial activity against common uropathogens on par with that of common antibiotics. By enabling the efficient retrieval of kidney stone fragments, our method can lead to improved stone-free rates and patient outcomes. The success of surgical kidney stone removal is limited by the ability to efficiently retrieve stone fragments, resulting in incomplete stone clearance and subsequent morbidity. Here, the authors show the efficacy and biocompatibility of a magnetic hydrogel that selectively coats human kidney stone fragments in vitro allowing their total extraction using a magnetic wire.
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影响因子：
23.4
作者：
de la Rosette, Jean J. M. C. H.;Skrekas, Thomas;Segura, Joseph W.
通讯作者：
Segura, Joseph W.
影响因子：
2
作者：
Kos, Mojca Kerec;Bogataj, Marija;Mrhar, Ales
通讯作者：
Mrhar, Ales
影响因子：
3.1
作者：
Cloutier, J.;Cordeiro, E. R.;Traxer, Olivier
通讯作者：
Traxer, Olivier
影响因子：
5.6
作者：
Bullivant JP;Zhao S;Willenberg BJ;Kozissnik B;Batich CD;Dobson J
通讯作者：
Dobson J
金属间化合物 ErPd2Si2 单晶中独特的流动自旋密度波和局部矩反铁磁性
影响因子：
4.6
作者：
Li HF;Cao C;Wildes A;Schmidt W;Schmalzl K;Hou B;Regnault LP;Zhang C;Meuffels P;Löser W;Roth G
通讯作者：
Roth G