Materials characterization of Feraheme/ferumoxytol and preliminary evaluation of its potential for magnetic fluid hyperthermia.
Materials characterization of Feraheme/ferumoxytol and preliminary evaluation of its potential for magnetic fluid hyperthermia.
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DOI：
10.3390/ijms140917501
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发表时间：
2013-08-26
影响因子：
5.6
通讯作者：
Dobson J
中科院分区：
文献类型：
--
作者：
Bullivant JP;Zhao S;Willenberg BJ;Kozissnik B;Batich CD;Dobson J
Feraheme是一种最近获得FDA批准的基于超顺磁性纳米氧化铁(SPION)的磁共振造影剂，也用于治疗缺铁性贫血。铁血红素纳米粒子的流体力学直径为30 nm，由氧化铁微晶与低分子量半合成碳水化合物复合而成。这些特征对其他潜在的生物医学应用也很有吸引力，如磁流体热疗(MFH)，因为羧化聚合物涂层提供了颗粒表面的功能化，并且其尺寸允许通过增强的渗透性和滞留效应在高度血管化的肿瘤中积累。本工作利用透射电子显微镜、能量色散X射线能谱和超导量子干涉装置(SQUID)的磁测量技术对费拉希石的形态和磁性进行了表征。此外，还描述了对Feraheme用于MFH应用的适宜性的初步评估结果，数据表明该粒子具有良好的应用性能。
Feraheme, is a recently FDA-cleared superparamagnetic iron oxide nanoparticle (SPION)-based MRI contrast agent that is also employed in the treatment of iron deficiency anemia. Feraheme nanoparticles have a hydrodynamic diameter of 30 nm and consist of iron oxide crystallites complexed with a low molecular weight, semi-synthetic carbohydrate. These features are attractive for other potential biomedical applications such as magnetic fluid hyperthermia (MFH), since the carboxylated polymer coating affords functionalization of the particle surface and the size allows for accumulation in highly vascularized tumors via the enhanced permeability and retention effect. This work presents morphological and magnetic characterization of Feraheme by transmission electron microscopy (TEM), Energy dispersive X-ray spectroscopy (EDX), and superconducting quantum interference device (SQUID) magnetometry. Additionally, the results of an initial evaluation of the suitability of Feraheme for MFH applications are described, and the data indicate the particles possess promising properties for this application.
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影响因子：
24.2
作者：
Stephen, Zachary R.;Kievit, Forrest M.;Zhang, Miqin
通讯作者：
Zhang, Miqin
影响因子：
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作者：
Kumar, Mohanraja;Medarova, Zdravka;Pantazopoulos, Pamela;Dai, Guangping;Moore, Anna
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作者：
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通讯作者：
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