Increased expression of lung resistance-related protein and multidrug resistance-associated protein messenger RNA in childhood acute lymphoblastic leukemia.
Increased expression of lung resistance-related protein and multidrug resistance-associated protein messenger RNA in childhood acute lymphoblastic leukemia.
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儿童急性淋巴细胞白血病中肺耐药相关蛋白和多药耐药相关蛋白信使 RNA 表达增加。
DOI：
10.1097/00043426-200001000-00009
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Safa,AR
中科院分区：
文献类型：
--
作者：
Ogretmen,B;Barredo,JC;Safa,AR
Immunophenotype might be an important indicator for multidrug resistance (MDR) profiles in childhood acute lymphoblastic leukemia (ALL). The authors analyzed the messenger RNA (mRNA) levels of MDR1, multidrug resistance-associated protein (MRP), and lung resistance-related protein (LRP) by reverse transcriptase-polymerase chain reaction (RT-PCR) in childhood pre-B ALL, T-cell ALL, and acute nonlymphoblastic leukemia (ANLL). Results showed that MRP and LRP, but not MDR1, mRNAs are overexpressed, particularly in children with pre-B ALL compared with T-cell ALL and ANLL tested. In addition, the MRP and LRP mRNA expression levels in initial diagnosis and first relapse samples of one patient with pre-B ALL were similar. Consequently, these preliminary results suggest that the expression of these MDR-related genes in childhood ALL might be regulated differently in a lineage dependent manner.
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影响因子：
20.3
作者：
SCHNEIDER, E;COWAN, KH;KAUFMANN, SH
通讯作者：
KAUFMANN, SH
从培养的人类细胞中小量制备用于 RT-PCR 的总 RNA。
DOI：
--
发表时间：
1995
期刊：
BioTechniques.
影响因子：
--
作者：
Ogretmen,B;Safa,AR
通讯作者：
Safa,AR
人类主要穹窿蛋白 LRP 在急性髓系白血病中的表达。
影响因子：
2.6
作者：
S. Hart;K. Ganeshaguru;R. Scheper;H. Prentice;A. Hoffbrand;A. Mehta
通讯作者：
A. Mehta
影响因子：
11.2
作者：
William T. Beck;T. M. Grogan;C. Willman;C. Cordon-Cardo;D. Parham;J. Kuttesch;Michael Andreeff;S. Bates;Costan W. Berard;James M. Boyett;N. Brophy;H. Broxterman;H. Chan;William S. Dalton;M. Dietel;A. Fojo;Randy D. Gascoyne;D. Head;P. Houghton;D. K. Srivastava;Manfred Lehnert;Catherine P. Leith;E. Paietta;Z. Pavelic;L. Rimsza;I. Roninson;B. Sikic;P. Twentyman;R. Warnke;R. Weinstein
通讯作者：
William T. Beck;T. M. Grogan;C. Willman;C. Cordon-Cardo;D. Parham;J. Kuttesch;Michael Andreeff;S. Bates;Costan W. Berard;James M. Boyett;N. Brophy;H. Broxterman;H. Chan;William S. Dalton;M. Dietel;A. Fojo;Randy D. Gascoyne;D. Head;P. Houghton;D. K. Srivastava;Manfred Lehnert;Catherine P. Leith;E. Paietta;Z. Pavelic;L. Rimsza;I. Roninson;B. Sikic;P. Twentyman;R. Warnke;R. Weinstein
mdrl、mrp、拓扑异构酶 IIα/β 和细胞周期蛋白 A 在急性淋巴细胞白血病原发或复发状态中的表达
DOI：
--
发表时间：
1995
期刊：
影响因子：
--
作者：
J. Beck;R. Handgretinger;R. Dopfer;T. Klingebiel;D. Niethammer;V. Gekeler
通讯作者：
V. Gekeler