Quality of life in adults with autism spectrum disorder: influence of age, sex, and a controlled, randomized mindfulness-based stress reduction pilot intervention.
Quality of life in adults with autism spectrum disorder: influence of age, sex, and a controlled, randomized mindfulness-based stress reduction pilot intervention.
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DOI：
10.1007/s11136-021-03013-x
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发表时间：
2022-05
影响因子：
3.5
通讯作者：
Ware, John E., Jr.
中科院分区：
文献类型：
--
作者：
Braden, B. Blair;Pagni, Broc A.;Monahan, Leanna;Walsh, Melissa J. M.;Dixon, Maria, V;Delaney, Shanna;Ballard, Lisa;Ware, John E., Jr.
与神经型（NT）同龄人相比，患有自闭症谱系障碍（ASD）的成年人一贯报告更差的功能健康和幸福感。在一系列研究中，我们旨在阐明性别，年龄及其相互作用对健康相关生活质量（HRQoL）的影响，并评估正念减压（MBSR）在改善ASD成人健康，残疾和自闭症相关生活质量方面的有效性，可能存在性别和年龄结果调节因素。研究1使用36项简表调查比较ASD成人（n = 67）和匹配的NT成人（n = 66）的精神和身体HRQoL综合评分。研究2是一项随机试点评估MBSR的效果，与社会支持和放松教育（支持/教育; n = 56）的积极控制干预相比，在世界卫生组织生活质量BREF，残疾和自闭症特异性量表中，ASD成年人。在研究1中，我们重复的结果，精神HRQoL是更糟的男性和女性ASD，相比NT同行，但身体HRQoL是只有更糟的女性ASD。我们提出了新的发现，老年与更好的精神HRQoL的女性ASD。在研究2中，MBSR改善残疾相关的生活质量在成人ASD以上的支持/教育干预，但这两种干预措施改善精神HRQoL。最后，这两种干预措施对ASD妇女的HRQoL改善更有效。研究结果鼓励针对年龄和性别群体的精准医学方法，以获得ASD成人的最佳HRQoL结果。NCT 04017793。
Adults with autism spectrum disorder (ASD) consistently report worse functional health and well-being, compared to neurotypical (NT) peers. In a series of studies, we aimed to elucidated the effects of sex, age, and their interaction on health-related quality of life (HRQoL) and evaluated the effectiveness of mindfulness-based stress reduction (MBSR) for improving health-, disability-, and autism-related QoL, with possible sex and age outcome moderators, in adults with ASD. Study 1 used the 36-Item Short Form Survey to compare mental and physical HRQoL composite scores in adults with ASD (n = 67) and matched NT adults (n = 66). Study 2 was a randomized pilot evaluation of the effect of MBSR, compared to an active control intervention with social support and relaxation education (support/education; n = 56), on the World Health Organization QoL BREF, Disability, and Autism-Specific scales in adults with ASD. In Study 1, we replicated findings that mental HRQoL is worse in both men and women with ASD, compared to NT counterparts, but physical HRQoL is only worse in women with ASD. We present novel findings that older age is associated with better mental HRQoL in women with ASD only. In Study 2, MBSR improved disability-related QoL in adults with ASD over and above the support/education intervention, but both interventions improved mental HRQoL. Lastly, both interventions were more effective for HRQoL improvements in women with ASD. Findings encourage precision medicine approaches tailored to age and sex groups for best HRQoL outcomes in adults with ASD. NCT04017793.
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DOI：
10.1016/j.invent.2020.100310
发表时间：
2020-04-01
影响因子：
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作者：
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通讯作者：
Newby, Jill M.