Designing a Mucoadhesive ChemoPatch to Ablate Oral Dysplasia for Cancer Prevention.
Designing a Mucoadhesive ChemoPatch to Ablate Oral Dysplasia for Cancer Prevention.
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DOI：
10.1002/smll.202201561
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发表时间：
2022-06
期刊：
影响因子：
--
通讯作者：
Tsai RYL
中科院分区：
文献类型：
--
作者：
Liu X;Li Q;Wang Y;Crawford M;Bhupal PK;Gao X;Xie H;Liang D;Cheng YL;Liu X;Tsai RYL
Oral cancer (OC) has a high mortality rate, and its treatment often causes debilitating complications. More than 90% of oral cancers are oral squamous cell carcinomas (OSCCs) that may develop from clinically recognizable oral premalignant lesions (OPLs). To eradicate OPLs before they turn into cancers, we develop a non-invasive topical formulation based on a novel combination of synergistically acting oxaliplatin (OXP) and mycophenolate (MPS) embedded in a controlled-release mucoadhesive patch fabricated by computer-aided 3-dimentional printing. After multiple rounds of testing and optimization, a v6.4 chemopatch is designed, which shows sustained release of OXP and MPS in vitro, minimal side leakage of drugs, an average elastic modulus of 2.38 MPa, and suitable drug stability at 4°C or below for up to 12 months. In vivo analyses show that almost all patches adhere to the dorsal tongue surface for 4 hours, and display a sustained release of OXP and MPS to tongue tissue for 3–4 hours. When applied in the 4NQO-induced OPL rat model, the OXP-MPS patch significantly ablates dysplastic lesions with no damage to normal epithelial cells and minimal systemic absorption and side effects. This study reports the design of a novel mucoadhesive chemopatch as a noninvasive therapy to treat OPLs. A novel mucoadhesive ChemoPatch is invented to provide a non-invasive therapeutic option for treating oral premalignant lesions, thereby preventing oral cancer formation. The design is based on a synergistically acting drug pairs, delivered by a 3-D-printed multi-layered mucoadhesive patch formulation in a controlled and sustained manner. Analyses of the mechanical, pharmacological, and biological properties of the ChemoPatch confirm its preclinical potential in treating oral precancer.
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影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Thun, Michael J.
通讯作者：
Thun, Michael J.
DOI：
10.1016/j.bbrc.2011.09.091
发表时间：
2011-10-22
影响因子：
3.1
作者：
Lin, Tao;Meng, Lingjun;Tsai, Robert Y. L.
通讯作者：
Tsai, Robert Y. L.
影响因子：
3.3
作者：
Moon, Sung-Min;Ahn, Mee-Young;Yoon, Jung-Hoon
通讯作者：
Yoon, Jung-Hoon
DOI：
10.1016/s0901-5027(05)80857-4
发表时间：
1995-02-01
影响因子：
2.4
作者：
NAUTA, M;ROODENBURG, JLN;VERMEY, A
通讯作者：
VERMEY, A
影响因子：
6
作者：
Crawford M;Johnson EH;Liu KYP;Poh C;Tsai RYL
通讯作者：
Tsai RYL