Are Several G Proteins Involved in the Different Effects of Endothelin‐1 in Mouse Striatal Astrocytes?
Are Several G Proteins Involved in the Different Effects of Endothelin‐1 in Mouse Striatal Astrocytes?
复制标题
几种 G 蛋白是否参与内皮素-1 对小鼠纹状体星形胶质细胞的不同作用？
DOI：
10.1111/j.1471-4159.1991.tb11421.x
复制
发表时间：
1991
影响因子：
4.7
通讯作者：
P. Couraud
中科院分区：
文献类型：
--
作者：
P. Marin;J. Delumeau;O. Durieu;D. Nguyen;J. Prémont;A. Strosberg;P. Couraud
摘要：通过 125I-ET-1 结合实验，在小鼠胚胎纹状体星形胶质细胞的原代培养物中鉴定出高亲和力特异性内皮素受体 (ET-1)。在 ET-1 刺激下，在相同细胞中观察到肌醇磷酸产生的刺激、细胞内钙浓度的双相增加以及环 AMP 积累的抑制。用百日咳博德特氏菌毒素预处理这些细胞会在不同程度上影响这些效应，这一观察结果表明它们是由多种转导途径介导的，可能涉及几种鸟嘌呤核苷酸结合蛋白。
Abstract: High‐affinity specific receptors of endothelin (ET‐1) were identified on primary cultures of mouse embryo striatal astrocytes by binding experiments performed with 125I‐ET‐1. Stimulation of production of inositol phosphates, a biphasic increase of the intracellular calcium concentration, and inhibition of cyclic AMP accumulation were observed in the same cells under ET‐1 stimulation. Pretreatment of these cells with Bordetella pertussis toxin affected these effects to different extends, an observation suggesting that they are mediated by multiple transduction pathways, possibly involving several guanine nucleotide‐binding proteins.
DOI：
10.1073/pnas.87.9.3454
发表时间：
1990-05-01
影响因子：
11.1
作者：
GLAUM, SR;HOLZWARTH, JA;MILLER, RJ
通讯作者：
MILLER, RJ
DOI：
10.1073/pnas.87.6.2359
发表时间：
1990-03-01
影响因子：
11.1
作者：
MACCUMBER, MW;ROSS, CA;SNYDER, SH
通讯作者：
SNYDER, SH
影响因子：
56.9
作者：
CORNELLBELL, AH;FINKBEINER, SM;SMITH, SJ
通讯作者：
SMITH, SJ